This is a randomized clinical trial of any therapy for Wegener's Granulomatosis (WG). The purpose of the study is to test whether blockade of TNF alpha results in clinical improvement in patients with limited and severe WG. The investigators will test the ability of etanercept to induce and maintain remission as standard therapies are tapered. The investigators plan to measure clinical outcome based on the standardized Birmingham vasculitis activity score (BVAS) instrument. They also plan to measure tapering of steroids and immunosuppressants as secondary outcomes. The trial combines two unique resources, the International Network for the Study of Systemic Vasculitides and the Centers for Clinical Studies at John Hopkins University. The study will be a double-blind, placebo-controlled, multicenter study involving 190 patients.

Project Start
1999-09-30
Project End
2004-06-30
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Suppiah, Ravi; Judge, Andrew; Batra, Rajbir et al. (2011) A model to predict cardiovascular events in patients with newly diagnosed Wegener's granulomatosis and microscopic polyangiitis. Arthritis Care Res (Hoboken) 63:588-96
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