Abstract

The specific objectives of this contract are: 1) to define the acute toxicities of new anticancer agents with advanced cancer; 2) to redefine the acute toxicities and pharmacokinetics of anticancer administered in combination with agents to modulate toxicity or antitumor effect; 3) to provide information on the pharmacokinetic characteristics (absorption, distribution, metabolism and elimination) and pharmacodynamics of selected antitumor agents; 4) to determine a treatment regimen suitable for evaluation of antitumor activity in Phase II trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM007302-002
Application #
3607830
Study Section
Project Start
1990-05-01
Project End
1995-05-31
Budget Start
1991-06-26
Budget End
1991-11-30
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

O'Reilly, S; Hartman, N R; Bowling, K M et al. (2001) Bioavailability of penclomedine and systemic exposure to 4-O-demethylpenclomedine in patients receiving oral and intravenous penclomedine. Cancer Chemother Pharmacol 48:223-8
Carducci, M A; Gilbert, J; Bowling, M K et al. (2001) A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. Clin Cancer Res 7:3047-55
O'Reilly, S; Grochow, L B; Donehower, R C et al. (1997) Phase I and pharmacologic study of penclomedine, a novel alkylating agent, in patients with solid tumors. J Clin Oncol 15:1974-84
O'Reilly, S; Rowinsky, E K; Slichenmyer, W et al. (1996) Phase I and pharmacologic study of topotecan in patients with impaired renal function. J Clin Oncol 14:3062-73
Hartman, N R; O'Reilly, S; Rowinsky, E K et al. (1996) Murine and human in vivo penclomedine metabolism. Clin Cancer Res 2:953-62
Rowinsky, E K; Kaufmann, S H; Baker, S D et al. (1996) Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence. J Clin Oncol 14:3074-84
Chaudhry, V; Rowinsky, E K; Sartorius, S E et al. (1994) Peripheral neuropathy from taxol and cisplatin combination chemotherapy: clinical and electrophysiological studies. Ann Neurol 35:304-11