Abstract

Conduct Phase I and Clinical Pharmacokinetic studies on specific investigational new drugs sponsored by the Division of Cancer Treatment (DCT), National Cancer Institute (NCI). The Contractor shall provide the parameters and characteristics of drug toxicity, the maximally tolerated dose, and recommend a phase II dose.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM057735-009
Application #
3613304
Study Section
Project Start
1985-06-08
Project End
1990-04-30
Budget Start
1989-06-29
Budget End
1989-11-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Rago, R P; Miles, J M; Sufit, R L et al. (1994) Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans. Cancer 73:1954-9
Bailey, H; Wilding, G; Tutsch, K D et al. (1992) A phase I trial of 5-fluorouracil, leucovorin, and dipyridamole given by concurrent 120-h continuous infusions. Cancer Chemother Pharmacol 30:297-302
Trump, D L; Egorin, M J; Forrest, A et al. (1991) Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole. J Clin Oncol 9:2027-35
Schiller, J H; Storer, B E; Witt, P L et al. (1991) Biological and clinical effects of intravenous tumor necrosis factor-alpha administered three times weekly. Cancer Res 51:1651-8
Bailey, H; Mulcahy, R T; Tutsch, K D et al. (1991) A phase I study of SR-2508 and cyclophosphamide administered by intravenous injection. Cancer Res 51:1099-104
Bailey, H; Tutsch, K D; Arzoomanian, R Z et al. (1991) Phase I clinical trial of fazarabine as a twenty-four-hour continuous infusion. Cancer Res 51:1105-8
Remick, S C; Grem, J L; Fischer, P H et al. (1990) Phase I trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion. Cancer Res 50:2667-72
Mulcahy, R T; Trump, D L (1988) Clinical chemosensitization by misonidazole and related compounds: a critical evaluation. J Clin Oncol 6:569-73
Trump, D L; Tutsch, K D; Willson, J K et al. (1987) Phase I clinical trial and pharmacokinetic evaluation of acodazole (NSC 305884), an imidazoquinoline derivative with electrophysiological effects on the heart. Cancer Res 47:3895-900
Trump, D L; Grem, J L; Tutsch, K D et al. (1987) Platinum analogue combination chemotherapy: cisplatin and carboplatin--a phase I trial with pharmacokinetic assessment of the effect of cisplatin administration on carboplatin excretion. J Clin Oncol 5:1281-9

Showing the most recent 10 out of 11 publications