The objectives of this project are to describe and evaluate the determinants of gastric dysplasia, intestinal metaplasia and chronic atrophic gastritis, conditions thought to be precursors to stomach cancer, in a population in Shandong, China where stomach cancer rates are high. This will be accomplished by continued followup of a population of 3,400 adults age 35-64 classified by (1) gastric status determined by gastroscopy; (2) diet, tobacco consumption, medical history and other exposures obtained via interviews; and (3) measurements of nutrients and other substances in blood, urine, and gastric juice. Rates of transitions of these gastric lesions to cancer will be determined via follow-up of the study population over a 6-year period.
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| Riecken, B; Pfeiffer, R; Ma, J L et al. (2002) No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med 34:22-8 |
| Groves, Frank D; Issaq, Haleem; Fox, Stephen et al. (2002) N-nitroso compounds and mutagens in Chinese fermented (sour) corn pancakes. J AOAC Int 85:1052-6 |
| You, W C; Zhang, L; Pan, K F et al. (2001) Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer. Ann Epidemiol 11:543-6 |
