The purpose of the contract is to 1) establish qualified clinical research units that, by building of existing research resources at the host institution and combining the necessary expertise in clinical pharmacology and child psychiatry, can become national resources where studies on the safety and efficacy of psychotropic medications can be conducted in a prompt and cost effective manner; and 2) fund selected research projects of particular public health significance, in particular in the area of autism and other pervasive developmental disorders, to be conducted at these units. The units, will work as a network of research sites and conduct high priority clinical studies in various pediatric ages, conducting research on various aspects of pediatric psychopharmacology, including (but not limited to): dose ranges, dosing regimen, pharmacokinetics, general safety profile, efficacy and effectiveness, and effects on cognition, behavior and development. To establish research units of where clinical studies on the safety, efficacy, pharmacokinetics and pharmacodynamics of psychotropic medications can be investigated in children and adolescents, in general, and in patients suffering from autism and other pervasive developmental disorders in particular. To conduct a minimum of 1 clinical trial of the efficacy of a psychotropic medication in children and/or adolescents with mood disorders. To spur the conduct of other clinical trials and studies in pediatric psychopharmacology to be funded through mechanisms other than this contract and in collaboration with other RUPPs (i.e., investigator-initiated grants from federal agencies, private foundations, and pharmaceutical companies).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research and Development Contracts (N01)
Project #
N01MH070008-003
Application #
6154519
Study Section
Project Start
1997-09-26
Project End
2000-09-30
Budget Start
1999-09-16
Budget End
2000-09-29
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Daviss, W Burleson; Perel, James M; Brent, David A et al. (2006) Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: an exploratory study. Ther Drug Monit 28:190-8
Daviss, W Burleson; Perel, James M; Rudolph, George R et al. (2005) Steady-state pharmacokinetics of bupropion SR in juvenile patients. J Am Acad Child Adolesc Psychiatry 44:349-57