Abstract

We are performing late Phase I and Phase II studies of naloxone in treatment of patients with acute cerebral ischemia. The late Phase I study will evaluate the efficacy and potential side effects of esculating doses of naloxone. The PhaseII study will evaluate the efficacy of an optimal dose of naloxone in treating patients with acute ischemic cardiovascular disease. If the results of the Phase I and Phase II trials suggest that large doses of naloxone are effective, then a randomized double blind trial could be performed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS032326-004003
Application #
3669531
Study Section
Project Start
1987-08-17
Project End
1989-08-16
Budget Start
1988-06-06
Budget End
1989-08-16
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Adams Jr, H P; Woolson, R F; Biller, J et al. (1992) Studies of Org 10172 in patients with acute ischemic stroke. TOAST Study Group. Haemostasis 22:99-103
Massey, E W; Biller, J; Davis, J N et al. (1990) Large-dose infusions of heparinoid ORG 10172 in ischemic stroke. Stroke 21:1289-92
Gordon, D L; Linhardt, R; Adams Jr, H P (1990) Low-molecular-weight heparins and heparinoids and their use in acute or progressing ischemic stroke. Clin Neuropharmacol 13:522-43
Olinger, C P; Adams Jr, H P; Brott, T G et al. (1990) High-dose intravenous naloxone for the treatment of acute ischemic stroke. Stroke 21:721-5
Biller, J; Massey, E W; Marler, J R et al. (1989) A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke. Neurology 39:262-5
Barsan, W G; Olinger, C P; Adams Jr, H P et al. (1989) Use of high dose naloxone in acute stroke: possible side-effects. Crit Care Med 17:762-7
Adams Jr, H P; Olinger, C P; Barsan, W G et al. (1986) A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia. Stroke 17:404-9