ADMINISTRATIVE COREThe University of Louisville Alcohol Research Center (ULARC) is a multidisciplinary program focusing onalcohol-nutrient interactions and alcohol-induced organ injury, and their prevention and/or treatment. Basicscience and clinical investigators from several departments within the School of Medicine, the DentalSchool, the Kent School of Social Work and the School of Public Health and Information Sciences havecoalesced into a cohesive research unit to examine selected research questions regarding the specificnutrient interactions in organ and systemic sequelae of alcohol abuse. The Center will be administrativelylocated within the Department of Medicine at the U of L Health Sciences Center. The Principal Investigatorand Center Director, Dr. Craig McClain, reports to the Executive Vice President for Health Sciences of theUniversity of Louisville, Dr. Larry Cook. Administrative support for the Center will be provided by the CenterBiostatistician, Dr. Datta, and a half-time administrator. The Executive Committee will be the guiding groupfor the ULARC. In addition, the External Advisory Committee and the Internal Advisory Committee willprovide oversight and consultation. The theme of alcohoknutrient interactions and alcohol-induced organinjury is unique and innovative amongst alcohol centers. The administrative core has a major educationfocus, including the development of a K-12 type program for translational investigators. The administrativecore focuses on collaborative interactions and mentoring (examples of both are highlighted). Innovation andtranslational research, with a goal of transforming clinical practice, are important directions for theAdministrative Core. The Administrative Core will be established to: 1) provide direction and prioritization ofULARC activities and assure proper accounting of grant monies; 2) coordinate the activities of the SupportCore and pilot projects; 3) ensure the quality of all ULARC functions; 4) develop a curriculum to train clinicaland translational alcohol researchers; and 5) disseminate pertinent information to ULARC investigators andthe scientific and lay community.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
1P01AA017103-01
Application #
7407954
Study Section
Special Emphasis Panel (ZAA1-BB (90))
Project Start
2008-09-30
Project End
2011-08-31
Budget Start
2007-12-01
Budget End
2009-08-31
Support Year
1
Fiscal Year
2008
Total Cost
$450,000
Indirect Cost
Name
University of Louisville
Department
Type
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Vatsalya, Vatsalya; Kong, Maiying; Cave, Matthew C et al. (2018) Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients. J Nutr Biochem 59:49-55
Poole, Lauren G; Beier, Juliane I; Torres-Gonzales, Edilson et al. (2018) Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung. Alcohol :
Hudson, Shanice V; Dolin, Christine E; Poole, Lauren G et al. (2017) Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Sci Rep 7:12444
McClain, Craig; Vatsalya, Vatsalya; Cave, Matthew (2017) Role of Zinc in the Development/Progression of Alcoholic Liver Disease. Curr Treat Options Gastroenterol 15:285-295
Song, Ming; Chen, Theresa; Prough, Russell A et al. (2016) Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response. Alcohol Clin Exp Res 40:518-28
Ghare, Smita S; Donde, Hridgandh; Chen, Wei-Yang et al. (2016) Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro 35:66-76
Chen, Wei-Yang; Zhang, Jingwen; Ghare, Smita et al. (2016) Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. Cell Mol Gastroenterol Hepatol 2:685-700
Liu, Yanlong; Zhao, Cuiqing; Xiao, Jian et al. (2016) Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. Sci Rep 6:31026
Zhao, Cuiqing; Liu, Yanlong; Xiao, Jian et al. (2015) FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. J Lipid Res 56:1481-91
Moghe, Akshata; Ghare, Smita; Lamoreau, Bryan et al. (2015) Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci 143:242-55

Showing the most recent 10 out of 57 publications