Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI035225-04
Application #
2070735
Study Section
Special Emphasis Panel (SRC (23))
Project Start
1993-09-30
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Blazar, Bruce R; Levy, Robert B; Mak, Tak W et al. (2004) CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol 173:2933-41
Chen, Zong-ming; O'Shaughnessy, Matthew J; Gramaglia, Irene et al. (2003) IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function. Blood 101:5076-83
Blazar, Bruce R; Carreno, Beatriz M; Panoskaltsis-Mortari, Angela et al. (2003) Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171:1272-7
Taylor, Patricia A; Friedman, Thea M; Korngold, Robert et al. (2002) Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 99:4601-9
Taylor, Patricia A; Lees, Christopher J; Wilson, Jessica M et al. (2002) Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions. Blood 100:3400-7
Gonzalez, Mercedes; Quezada, Sergio A; Blazar, Bruce R et al. (2002) The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. J Immunol 169:5581-9
Taylor, Patricia A; Lees, Christopher J; Blazar, Bruce R (2002) The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493-9
Blazar, B R; Lindberg, F P; Ingulli, E et al. (2001) CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med 194:541-9
Taylor, P A; Lees, C J; Waldmann, H et al. (2001) Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions. Blood 98:467-74
Prlic, M; Blazar, B R; Khoruts, A et al. (2001) Homeostatic expansion occurs independently of costimulatory signals. J Immunol 167:5664-8

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