Taenia solium cysticercosis is the main cause of acquired epilepsy in the world. The infection is highly endemic in most developing countries, and recent studies by our group have demonstrated that the antibody-positive population is composed of an ?iceberg? structure involving exposure, established infection, and symptomatic disease. At the same time, our group has advanced in the determination of some of the most important antigenic components of the parasite. We have sequenced and synthesized two of them, and are in the process of synthesizing several others. In this project we will use these synthetic antigens or combinations of them, as well as two monoclonal-antibody based antigen detection assays, to look for a sensitive and specific assay that can permit to discriminate individuals with viable cysts. In the human population, it is expectable that a proportion of individuals with established neurocysticercosis (NCC) will develop neurological symptoms in the lapse of a few years.
We aim to detect individuals with latent viable NCC to determine in a clinical trial if preventive antiparasitic therapy may prevent neurological symptoms. Finally, a simulation model will be developed in order to evaluate whether the benefits of this treatment may outweigh the costs associated with screening, detection, and treatment of asymptomatic NCC cases.
|Gonzales, Isidro; Miranda, J Jaime; Rodriguez, Silvia et al. (2015) Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. Trop Med Int Health 20:546-52|
|Salazar-Salinas, Karim; Baldera-Aguayo, Pedro A; Encomendero-Risco, Jimy J et al. (2014) Metal-ion effects on the polarization of metal-bound water and infrared vibrational modes of the coordinated metal center of Mycobacterium tuberculosis pyrazinamidase via quantum mechanical calculations. J Phys Chem B 118:10065-75|
|Wang, Yuanfei; Yang, Wenli; Cama, Vitaliano et al. (2014) Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission. Int J Parasitol 44:515-21|
|Arriola, Carmen S; Gonzalez, Armando E; Gomez-Puerta, Luis A et al. (2014) New insights in cysticercosis transmission. PLoS Negl Trop Dis 8:e3247|
|Li, Na; Xiao, Lihua; Cama, Vitaliano A et al. (2013) Genetic recombination and Cryptosporidium hominis virulent subtype IbA10G2. Emerg Infect Dis 19:1573-82|
|Gavidia, Cesar M; Verastegui, Manuela R; Garcia, Hector H et al. (2013) Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis 7:e2192|
|Sheen, Patricia; Lozano, Katherine; Gilman, Robert H et al. (2013) pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb) 93:515-22|
|Sheen, Patricia; Ferrer, Patricia; Gilman, Robert H et al. (2012) Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase. Am J Trop Med Hyg 87:153-61|
|Zimic, Mirko; Fuentes, Patricia; Gilman, Robert H et al. (2012) Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance. Tuberculosis (Edinb) 92:84-91|
|Rossi, Andrea; Marqués, Juan M; Gavidia, Cesar M et al. (2012) Echinococcus granulosus: different cytokine profiles are induced by single versus multiple experimental infections in dogs. Exp Parasitol 130:110-5|
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