BEAMS ABSTRACT: Core D The Data Science Core (Core D) will provide expertise in data management and integration, statistics, bioinformatics, and computing to all projects and cores in this Program Project Grant (PPG). Core D is composed of quantitative scientists with extensive experience in pediatric asthma cohort studies, data management and integration, and the development and application of novel analysis methods for microbiome, RNA-Seq, and other omics technologies. Core D will provide coordinated statistical study design and analysis to all projects, statistical learning and informatics functionality for omics studies, and an integrated data management platform, that supports project goals and facilitates investigator access to multi-project integrated data sets and custom analysis tools. Core D data scientists make extensive use of modern methods of statistical computing and reproducible research tools. This capability fosters the sharing of analysis code and results, the rapid deployment of novel analysis tools, and effective investigator access to program-wide data and knowledge management platforms for cross-project research discovery. Core D is a vital component of each project in this PPG. Core D will facilitate the discovery of novel scientific results describing how prenatal and early life environmental exposures shape gut microbial colonization and immune system development, and confer an asthma-protective effect.
