The primary objective is to determine whether fast neutron theraphy is superior to the best current treatment methods in the management of locally advanced malignant tumors. To achieve this goal, cooperative clinical trials have been initiated under the direction of the Radiation Therapy Oncology Group. The majority of these trials are randomized studies comparing neutron therapy with ceonventional treatment by surgery, photon irradiation, or combined surgery and photon irradiation. In addition to a continuation of the clinical trial in human cancer, research in physics and radiobiology will be carried out in order to (1) improve neutron treatment techniques and dosage schedules, (2) evaluate acute and late effects on normal tissues, (3) explore the potential for combinations with other treatment modalities, and (4) define a patient population for future clinical trials. Between 1972 and 1980, the M.D. Anderson neutron therapy program used the 50MeV(d Be) TAMVEC cyclotron located at Texas A&M University, 100 miles from Houston. The program is now being transferred to M. D. Anderson Hospital where a 42MeV(p BE) cyclotron specifically designed for neutron therapy and cancer research is being installed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA012542-13
Application #
3092570
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1978-08-01
Project End
1985-09-30
Budget Start
1985-02-01
Budget End
1985-09-30
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
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Peters, L J; Maor, M H; Laramore, G E et al. (1985) Review of clinical results of fast neutron therapy in the USA. Strahlentherapie 161:731-8
Savary, C A; Lotzova, E; Gray, K N et al. (1985) Natural killer cell-mediated antitumor reactivity of rhesus monkeys. Nat Immun Cell Growth Regul 4:328-39