Abstract

This project proposes to define the effects of organ preservation protocols involving high dose radiotherapy (5000+ cGy) with or without chemotherapy in 300 oral, laryngeal, and pharyngeal cancer patients with previously untreated Stages II to IV disease, and to measure the effectiveness of swallow maneuvers in improving the swallow. Each patient will be followed for 12 months after treatment completion. All patients will be studied pretreatment, and at 1 month, 3 months, 6 months and 12 months post completion of chemoradiotherapy. At each of these data collection points, each patient will receive a videofluoroscopic assessment of swallowing, a voice recording for acoustic analysis, and a speech analysis for understandability and articulatory production. Patients assessed at Northwestern University will receive manometry concurrent with videofluoroscopy. The radiographic studies of swallowing will be analyzed in detail for the physiologic swallowing disorders present, and the temporal and biomechanical characteristics of the swallow. Manometric studies will be analyzed for amplitude of pharyngeal contraction and hypopharyngeal bolus pressures. The voice recordings will undergo detailed acoustic analysis. The speech recordings will be examined for conversational understandability and percent correct articulation. Each patient's response to swallow maneuvers will be defined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA040007-14
Application #
6102210
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201

  Publications

Logemann, Jerilyn A (2014) Critical Factors in the Oral Control Needed for Chewing and Swallowing. J Texture Stud 45:173-179
Pauloski, Barbara Roa; Logemann, Jerilyn A; Rademaker, Alfred W et al. (2013) Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer. Head Neck 35:1124-31
Pauloski, Barbara Roa; Rademaker, Alfred W; Lazarus, Cathy et al. (2009) Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia 24:196-203
Logemann, Jeri A; Pauloski, Barbara Roa; Rademaker, Alfred W et al. (2008) Swallowing disorders in the first year after radiation and chemoradiation. Head Neck 30:148-58
Pauloski, Barbara Roa; Rademaker, Alfred W; Logemann, Jerilyn A et al. (2006) Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck 28:1069-76
Daggett, Alicia; Logemann, Jeri; Rademaker, Alfred et al. (2006) Laryngeal penetration during deglutition in normal subjects of various ages. Dysphagia 21:270-4
Smith, Christina H; Logemann, Jeri A; Burghardt, Wesley R et al. (2006) Oral and oropharyngeal perceptions of fluid viscosity across the age span. Dysphagia 21:209-17
Logemann, Jeri A; Rademaker, Alfred W; Pauloski, Barbara Roa et al. (2006) Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck 28:64-73
Logemann, Jeri A; Williams, Rohan B; Rademaker, Alfred et al. (2005) The relationship between observations and measures of oral and pharyngeal residue from videofluorography and scintigraphy. Dysphagia 20:226-31
Waters, Teresa M; Logemann, Jeri A; Pauloski, Barbara Roa et al. (2004) Beyond efficacy and effectiveness: conducting economic analyses during clinical trials. Dysphagia 19:109-19

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