Abstract

The mission of the Tea Chemistry and Analysis (TC&R) Core is to facilitate the research activities of the four Projects of this Program Project by providing well-characterized tea preparations and purified tea constituents/metabolites and performing chemical analyses that are required by the four Projects.
The specific aims are as follows: 1. Procure tea preparations and purify tea constituents. The caffeine and tea polyphenol contents in the tea preparations will be analyzed at the time of use. The stability of these compounds in solutions under experimental condition will be determined. 2. Determine plasma/tissue levels of catechins, caffeine, and their metabolites in selected samples from Projects 1 and 2. 3. Analyze the fatty acid compositions of fat pad samples from Projects 1 and 2. 4. Synthesize catechin metabolites and radio labeled compounds. These include O-methyl, glucuronide, and sulfate derivatives of EGCG and EGC, catechin ring fission metabolites M4 and M6, and theasinesins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA088961-02
Application #
6654069
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-09-06
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Type
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Yang, Chung S; Zhang, Jinsong; Zhang, Le et al. (2016) Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res 60:160-74
Conney, Allan H; Lou, You-Rong; Nghiem, Paul et al. (2013) Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat. Top Curr Chem 329:61-72
Inoue-Choi, Maki; Yuan, Jian-Min; Yang, Chung S et al. (2010) Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers. Int J Mol Epidemiol Genet 1:114-123
Lambert, Joshua D; Kennett, Mary J; Sang, Shengmin et al. (2010) Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food Chem Toxicol 48:409-16
Lee, Kyung Mi; Lee, Ki Won; Byun, Sanguine et al. (2010) 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. Cancer Prev Res (Phila) 3:454-65
Kwon, Jung Yeon; Lee, Ki Won; Kim, Jong-Eun et al. (2009) Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis 30:1932-40
Lee, Kyung Mi; Lee, Ki Won; Bode, Ann M et al. (2009) Tpl2 is a key mediator of arsenite-induced signal transduction. Cancer Res 69:8043-9
Bode, Ann M; Cho, Yong-Yeon; Zheng, Duo et al. (2009) Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res 69:905-13
Fedorov, Sergey N; Radchenko, Oleg S; Shubina, Larisa K et al. (2008) Anticancer activity of 3-demethylubiquinone Q2. In vivo experiments and probable mechanism of action. Anticancer Res 28:927-32
Lu, Gang; Xiao, Hang; You, Hui et al. (2008) Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin. Clin Cancer Res 14:4981-8

Showing the most recent 10 out of 111 publications