An Administrative Core, Core A, is in operation which will continue to be responsible for the overall scientific guidance and for providing seamless day-to-day management and organization. Specifically, the Administrative Core provides: (1) The Steering Committee, chaired by the PI and composed of the projectand core leaders, that meets monthly. This steering committee has been in charge of assessing progress and enhancing interactions among the projects. Also, this committee will oversee the appropriate functions of the Cores. This committee is responsible for making decisions on fiscal issues as well (e.g. re-allocation of funds) through consensus. (2) The Program Group composed of the PI, the project leaders and co- PI's of each of the projects, postdoctoral fellows and students, the director of the Lipidomics Core and Associate Directors, and the Director of the SL Animal Core. This scientific group already meets at least once a month (every third Thursday at noon for 2 hours) and will continue to do so. In these meetings the Program Group reviews progress by one of the projects and/or one of the cores. This group functions primarily to enhance the overall as well as specific scientific activities. In addition, review of key publications is undertaken in the form of a journal club. This group also discusses specific scientific and technical issues pertinent to the development of the projects and the overall program. (3) The Internal Advisory Committee. This committee has been most helpful in provide programmatic advice. This committee convenes at least twice a year for overall review and to offer advice on the future development of the program project at a scientific level. This group also helps advise and steer administrative issues within SBU. (4) The External Advisory Committee. This committee, composed of highly regarded scientists, has met once a year during the annual retreat of the Program Project, and it will continue to do so. It oversees the progress of the projects, the use of the Cores, and has been most helpful in discussions about strategy as well as most recently in discussions and recommendations on translational research. (5) Supervise the secretarial and business support of the program. The administrative manager will oversee the specific budgets of each projects and the cores, and will keep project leaders up to date on expenses versus budgets.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA097132-11A1
Application #
8742656
Study Section
Special Emphasis Panel (ZCA1-RPRB-J (M1))
Project Start
2002-07-01
Project End
2019-08-31
Budget Start
2014-09-22
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
$141,700
Indirect Cost
$50,940
Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Xu, Ruijuan; Garcia-Barros, Monica; Wen, Sally et al. (2018) Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ 25:841-856
Coant, Nicolas; Hannun, Yusuf A (2018) Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul :
Trayssac, Magali; Hannun, Yusuf A; Obeid, Lina M (2018) Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest 128:2702-2712
Munshi, Mansa A; Gardin, Justin M; Singh, Ashutosh et al. (2018) The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans. Cell Rep 22:1392-1400
Snider, Justin M; Snider, Ashley J; Obeid, Lina M et al. (2018) Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res 59:1046-1057
Li, Fang; Xu, Ruijuan; Low, Benjamin E et al. (2018) Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J 32:3058-3069
Pulkoski-Gross, Michael J; Jenkins, Meredith L; Truman, Jean-Philip et al. (2018) An intrinsic lipid-binding interface controls sphingosine kinase 1 function. J Lipid Res 59:462-474
Williams, Bianca; Correnti, Jason; Oranu, Amanke et al. (2018) A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis. FASEB J 32:130-142
Bai, Aiping; Bielawska, Alicja; Rahmaniyan, Mehrdad et al. (2018) Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem 26:6067-6075
Newcomb, Benjamin; Rhein, Cosima; Mileva, Izolda et al. (2018) Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res 59:1219-1229

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