The Animal Models and Pathology Core is established to provide essential animal and pathology resource components that comprehensively support research Projects utilizing animal models.
The Specific Aims of this Core are:
Specific Aim 1 - To maintain quality controlled breeding colonies for various mouse strains;
Specific Aim 2 - To develop novel strains of transgenic mice and maintain breeding colonies of mice that will be specifically utilized by individual Projects in the Program;
Specific Aim 3 - To generate mouse embryonic fibroblasts (MEFs) from various mice strains proposed in individual projects;
Specific Aim 4 - To provide animal pathology services for in vivo cancer models;
and Specific Aim 5 - To provide services for tumor tissue staining and characterization by IHC and TMA.
The central objective of the Animal Models and Pathology Core is to provide the PPG investigators with the knowledge, resources, and ability to utilize animal models, pathological examination, and analyses in the execution of their research projects and their advancement to preclinical studies. The Core is an integral part of the research program with regard to examination of lipid metabolism and signaling mechanisms involved in the pathogenesis and treatment of solid tumors.
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|Schrecengost, Randy S; Green, Cecelia L; Zhuang, Yan et al. (2018) In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther 365:107-116|
|Ogretmen, Besim (2018) Sphingolipid metabolism in cancer signalling and therapy. Nat Rev Cancer 18:33-50|
|Helke, Kristi; Angel, Peggi; Lu, Ping et al. (2018) Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep 8:1627|
|Chatterjee, Shilpak; Daenthanasanmak, Anusara; Chakraborty, Paramita et al. (2018) CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab 27:85-100.e8|
|Panneer Selvam, Shanmugam; Roth, Braden M; Nganga, Rose et al. (2018) Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. J Biol Chem 293:9784-9800|
|Britten, Carolyn D; Garrett-Mayer, Elizabeth; Chin, Steven H et al. (2017) A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res 23:4642-4650|
|Lv, Zongyang; Rickman, Kimberly A; Yuan, Lingmin et al. (2017) S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell 65:699-714.e6|
|Thomas, Raquela J; Oleinik, Natalia; Panneer Selvam, Shanmugam et al. (2017) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med 9:1030-1051|
|Scheffel, Matthew J; Helke, Kristi; Lu, Ping et al. (2017) Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep 7:15552|
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