This program project is concerned with individual differences in behavioral and neurochemical response to cocaine. It is designed to characterize the influence of genetics on the individual cocaine-related processes measured, and on the correlations among them. It will furthermore identify the chromosome regions wherein are located effective genetic loci accounting for as little as 15 per cent of the phenotypic variance. This information will be used to breed selectively to generate lines of animals differing with respect to two of the most influential of these loci and both in combination, with the rest of their genotypes being randomly distributed. These lines will constitute powerful models for investigating the mechanisms underlying the genetic influence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA007171-02
Application #
2119447
Study Section
Special Emphasis Panel (SRCD (17))
Project Start
1991-07-01
Project End
1996-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802