The research consists of eight projects, each with its own individual goals and objectives, but bound together by a common developmental theme. The studies all address some aspect of the manner in which development and eventual clinical outcome are influenced by intervening variables, and all share the ultimate goal of improving the care of people with clefts of the lip and palate by expanding our knowledge about a variety of factors that control or influence the results of treatment and by seeking ways to change treatment as the result of improved understanding. Post-natal development in individuals with clefts is the focus of our studies which share the common goal of discovering how various developmental factors are related to problems of the middle ear, audition, stature, and speech. The Speech Science Project is composed of seven related substudies and seeks to determine the roles played by a variety of physical, physiological, and developmental attributes with the ultimate goal being the development of a model of velopharyngeal valving. Understanding this important system will lead to improved methods of treating congenital abnormalities that affect it. The second group of studies consists of four projects which seek to determine either how certain relevant structures develop or how they are influenced by intervening variables. These studies incorporate animal or fetal material rather than human subjects, but they all have the goal of explaining how outcome may be influenced by developmental characteristics or by various forms of intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE001697-28
Application #
3094910
Study Section
Special Emphasis Panel (SSS (B))
Project Start
1977-12-01
Project End
1991-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
28
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Dentistry
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Edington, H D; Mooney, M P; Losken, A et al. (1998) The effects of soft-tissue expansion on lip repair and midfacial growth in a rabbit cleft lip model. Ann Plast Surg 41:171-9
Smith, T D; Siegel, M I; Mooney, M P et al. (1997) Formation and enlargement of the paranasal sinuses in normal and cleft lip and palate human fetuses. Cleft Palate Craniofac J 34:483-9
Smith, T D; Siegel, M I; Mooney, M P et al. (1997) Prenatal growth of the human vomeronasal organ. Anat Rec 248:447-55
Vergato, L A; Doerfler, R J; Mooney, M P et al. (1997) Mouse palatal width growth rates as an ""at risk"" factor in the development of cleft palate induced by hypervitaminosis A. J Craniofac Genet Dev Biol 17:204-10
Smith, T D; Siegel, M I; Mooney, M P et al. (1996) Vomeronasal organ growth and development in normal and cleft lip and palate human fetuses. Cleft Palate Craniofac J 33:385-94
Anemone, R L; Mooney, M P; Siegel, M I (1996) Longitudinal study of dental development in chimpanzees of known chronological age: implications for understanding the age at death of Plio-Pleistocene hominids. Am J Phys Anthropol 99:119-33
Elliott, M A; Studen-Pavlovich, D A; Ranalli, D N (1995) Prevalence of selected pediatric conditions in children with Pierre Robin sequence. Pediatr Dent 17:106-11
Mooney, M P; Siegel, M I; Kimes, K R et al. (1994) Anterior paraseptal cartilage development in normal and cleft lip and palate human fetal specimens. Cleft Palate Craniofac J 31:239-45
Losken, A; Mooney, M P; Siegel, M I (1994) Comparative cephalometric study of nasal cavity growth patterns in seven animal models. Cleft Palate Craniofac J 31:17-23
Paradise, J L; Elster, B A; Tan, L (1994) Evidence in infants with cleft palate that breast milk protects against otitis media. Pediatrics 94:853-60

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