Project 2 will test the hypothesis that injury to the renal papilla as documented by our papillary injury grading system (PGS) will reflect and predict stone disease, specifically we will determine the influence of intrinsic patient factors such as renal physiology and stone passage events, as well as on the influence of extrinsic patient factors, particularly surgical treatments. To investigate the time course of papillary disease, we will quantify the extent of papillary changes in a co-hort of pediatric calcium stone formers. We will test the hypothesis that our PGS will predict calcium stone type, as well as the relative percentage of calcium phosphate present in stones. In a related hypothesis, we will test whether application of the PGS is able to predict calcium stone type as classified by formation pattern (tubular plugging vs plaque overgrowth). We hypothesize that papilla with high injury scores will correlate with renal injury as quantified by cimetidine blocked creatinine clearance and microalbuminuria. We have documented that tubular plugging is histologically associated with significant inflammatory changes in the papilla. We will test the hypothesis that these changes will be reflected by elevated levels of inflammatory markers in urine, as well as tissue. We have previously documented that percantage of Randall's plaque papillary coverage correlates directly with stone activity. We will determine whether papillary injury is also associated with stone activity. Finally, we will test the hypothesis that inflammation secondary to ductal plugging is associated with chronic flank pain in the setting of non-obstructing renal stones and, further, whether the treatment of such stones is associated with improvement in patient symptoms.
| Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192 |
| Worcester, Elaine M; Bergsland, Kristin J; Gillen, Daniel L et al. (2018) Mechanism for higher urine pH in normal women compared with men. Am J Physiol Renal Physiol 314:F623-F629 |
| Bergsland, Kristin J; Coe, Fredric L; Parks, Joan H et al. (2018) Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. Nephrol Dial Transplant 33:759-770 |
| Kleinguetl, Colin; Williams Jr, James C; Ibrahim, Samar A et al. (2017) Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney Stone. J Endourol Case Rep 3:192-195 |
| Mulay, Shrikant R; Eberhard, Jonathan N; Desai, Jyaysi et al. (2017) Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease. J Am Soc Nephrol 28:761-768 |
| Winfree, Seth; Khan, Shehnaz; Micanovic, Radmila et al. (2017) Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells. J Am Soc Nephrol 28:2108-2118 |
| Borofsky, Michael S; Dauw, Casey A; York, Nadya et al. (2017) Accuracy of daily fluid intake measurements using a ""smart"" water bottle. Urolithiasis : |
| Winfree, Seth; Ferkowicz, Michael J; Dagher, Pierre C et al. (2017) Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications. Transl Res 189:1-12 |
| Cohen, Andrew J; Borofsky, Michael S; Anderson, Blake B et al. (2017) Endoscopic Evidence That Randall's Plaque is Associated with Surface Erosion of the Renal Papilla. J Endourol 31:85-90 |
| Gilad, Ron; Williams Jr, James C; Usman, Kalba D et al. (2017) Interpreting the results of chemical stone analysis in the era of modern stone analysis techniques. J Nephrol 30:135-140 |
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