Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
3P01ES011854-03S1
Application #
6935577
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Kirshner, Annette G
Project Start
2002-08-01
Project End
2006-07-31
Budget Start
2004-09-02
Budget End
2005-07-31
Support Year
3
Fiscal Year
2004
Total Cost
$434,396
Indirect Cost

  Institution

Name
University of Rochester
Department
Orthopedics
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Beier, Eric E; Holz, Jonathan D; Sheu, Tzong-Jen et al. (2016) Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice. Toxicol Sci 149:277-88
Shu, Lei; Beier, Eric; Sheu, Tzong et al. (2015) High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcif Tissue Int 96:313-23
Beier, Eric E; Inzana, Jason A; Sheu, Tzong-Jen et al. (2015) Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice. Environ Health Perspect 123:935-43
Beier, Eric E; Sheu, Tzong-Jen; Dang, Deborah et al. (2015) Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/?-CATENIN SIGNALING PATHWAY. J Biol Chem 290:18216-26
Beier, Eric E; Sheu, Tzong-Jen; Buckley, Taylor et al. (2014) Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing. J Orthop Res 32:1397-405
Beier, Eric E; Maher, Jason R; Sheu, Tzong-Jen et al. (2013) Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling. Environ Health Perspect 121:97-104
Holz, Jonathan D; Beier, Eric; Sheu, Tzong-Jen et al. (2012) Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-? signaling. J Orthop Res 30:1760-6
van Wijngaarden, Edwin; Campbell, James R; Cory-Slechta, Deborah A (2009) Bone lead levels are associated with measures of memory impairment in older adults. Neurotoxicology 30:572-80
Campbell, James R; Auinger, Peggy (2007) The association between blood lead levels and osteoporosis among adults--results from the third national health and nutrition examination survey (NHANES III). Environ Health Perspect 115:1018-22
Zuscik, Michael J; Ma, Lin; Buckley, Taylor et al. (2007) Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Environ Health Perspect 115:1276-82

Showing the most recent 10 out of 17 publications