The objective is to conduct an integrated, multidisciplinary inquiry into the psychophysiology of cardiovascular reactivity. Our goal is to use psychophysiological, neurobiological, and behavioral methods to study cardiovascular regulatory processes, relationships between behavior and chronic disorders, and the development of efficacious treatments. The Project consists of four major areas, together with Core facilities supporting the program with biochemical urinary and plasma assays, computation/instrumentation, and psychophysiological data collection. The Cores contribute substantially to the implementation of each Project by using common methodological approaches. Project 1 will examine why black Americans have double the prevalence of hypertension as whites. The manner in which biobehavioral and psychosocial factors influence cardiovascular adjustments and neuroregulatory processes as a function of sex, race, and blood pressure level (normotension vs. borderline hypertension) will be examined during psychophysiological reactivity tasks in the laboratory and during ambulatory heart rate, blood pressure, and hormonal monitoring in natural settings. Project 2 will examine in mild or moderate hypertensives how beta blockers differing in selectivity, lipophilicity, and intrinsic sympathetic activity influence as a function of race and sex: (a) hemodynamic and hormonal reactivity to standardized behavioral challenges in the laboratory; (b) heart rate, blood pressure, and hormonal activity during ambulatory monitoring, (c) cognitive performance, (d) mood, and (e) fatigue. Project 3 will use psychophysiological reactivity tasks, autonomic function tests, and ambulatory monitoring in Type 1 diabetics to investigate: (a) interrelationships among autonomic function, glycemia, cardiovascular and neurohormonal reactivity, and behavior; (b) putative pathophysiological mechanisms responsible for autonomic neuropathy; (c) influences of psychosocial stressors and personality factors on pharmacologic, and/or behavioral interventions designed to exert glycemic control and moderate autonomic reactivity; and (d) influences of anti-hypertensive therapies upon glycemia, autonomic function, reactivity, and behavior. Project 4 will examine in rabbits, the CNS mechanisms underlying cardiovascular reactivity, and will assess the degree to which sympathetic nervous system induced reactivity is attenuated by behavioral conditioning or direct activation of sympathoinhibitory CNS pathways.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Research Review Committee A (HLBA)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Miami Coral Gables
Schools of Arts and Sciences
Coral Gables
United States
Zip Code
Moncrieft, Ashley E; Llabre, Maria M; McCalla, Judith Rey et al. (2016) Effects of a Multicomponent Life-Style Intervention on Weight, Glycemic Control, Depressive Symptoms, and Renal Function in Low-Income, Minority Patients With Type 2 Diabetes: Results of the Community Approach to Lifestyle Modification for Diabetes Random Psychosom Med 78:851-60
Birnbaum-Weitzman, O; Goldberg, R; Hurwitz, B E et al. (2014) Depressive symptoms linked to 1-h plasma glucose concentrations during the oral glucose tolerance test in men and women with the metabolic syndrome. Diabet Med 31:630-6
Countryman, Amanda J; Saab, Patrice G; Schneiderman, Neil et al. (2014) Cardiovascular reactivity and cardiometabolic risk in adolescents. Int J Behav Med 21:122-30
Szeto, Angela; Rossetti, Maria A; Mendez, Armando J et al. (2013) Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits. Psychoneuroendocrinology 38:685-93
Chirinos, Diana A; Goldberg, Ronald; Gellman, Marc et al. (2013) Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Ann Behav Med 46:31-9
Noller, Crystal M; Szeto, Angela; Mendez, Armando J et al. (2013) The influence of social environment on endocrine, cardiovascular and tissue responses in the rabbit. Int J Psychophysiol 88:282-8
Hurwitz, Barry E (2012) Sleep Debt and Postprandial Metabolic Function in Subclinical Cardiometabolic Pathophysiology. Endocrinol Metab Syndr 1:
Raij, Leopoldo; Gonzalez-Ochoa, Alba M (2011) Vascular compliance in blood pressure. Curr Opin Nephrol Hypertens 20:457-64
Szeto, Angela; McCabe, Philip M; Nation, Daniel A et al. (2011) Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med 73:393-400
Nation, Daniel A; Szeto, Angela; Mendez, Armando J et al. (2010) Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice. Psychosom Med 72:376-82

Showing the most recent 10 out of 87 publications