The Murine Studies Core will perform studies proposed in Projects 2 and 3 related to allergen-induced airway hyperresponsiveness (AHR) in mice. In addition, Core A will provide murine pulmonary function testing including both lung resistance (RL) studies and barometric plethysmography with enhanced pause (Penh) measurements, as well as analyses of force generation in tracheal rings. Core A will also perform histological and cytological analyses, immunocytochernistry, and ELISA assays for cytokine levels in the bronchoalveolar lavage (BAL) as well as serum immunoglobulin levels from mice. Further, the Core will establish and maintain murine airway smooth muscle (ASM) and bronchial epithelial cell lines.
| Tliba, Omar; Panettieri Jr, Reynold A (2018) Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation. J Allergy Clin Immunol : |
| Komolov, Konstantin E; Du, Yang; Duc, Nguyen Minh et al. (2017) Structural and Functional Analysis of a ?2-Adrenergic Receptor Complex with GRK5. Cell 169:407-421.e16 |
| Carr 3rd, Richard; Benovic, Jeffrey L (2016) From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins. Biochem Soc Trans 44:555-61 |
| Puré, Ellen; Krolikoski, Mia; Monslow, Jamie (2016) Role for Hyaluronan Synthase 3 in the Response to Vascular Injury. Arterioscler Thromb Vasc Biol 36:224-5 |
| Panettieri Jr, Reynold A (2015) Bronchodilators, receptors and cross-talk: Together is better? Postgrad Med 127:771-80 |
| Jude, Joseph A; Tirumurugaan, Krishnaswamy G; Kang, Bit Na et al. (2012) Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases. Am J Respir Cell Mol Biol 47:427-35 |
| Goncharova, Elena A; Lim, Poay N; Chisolm, Amelia et al. (2010) Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 299:L25-35 |
| Dweik, Raed A; Sorkness, Ronald L; Wenzel, Sally et al. (2010) Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 181:1033-41 |
| Lara, Abigail; Khatri, Sumita B; Wang, Zeneng et al. (2008) Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med 178:673-81 |
| Comhair, Suzy A A; Ricci, Kristin S; Arroliga, Mercedes et al. (2005) Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 172:306-13 |
