The primary function of the Human Studies Core is to support individual research projects within the SCOR by providing the personnel, facilities, and structure to accomplish the following specific aims: (1) To generate and maintain an asthma patient database; (2) To provide a central facility using uniform criteria for recruiting and screening patients for clinical studies; (3) To provide a central facility for performing all bronchoscopic and airway challenge procedures; (4) To coordinate the distribution of patient specimens for analysis in individual projects; (5) To provide quality control and proper patient safeguards in the acquisition of patient specimens; and (6) To provide expertise in statistical analysis, study design, and data management.
| Tliba, Omar; Panettieri Jr, Reynold A (2018) Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation. J Allergy Clin Immunol : |
| Komolov, Konstantin E; Du, Yang; Duc, Nguyen Minh et al. (2017) Structural and Functional Analysis of a ?2-Adrenergic Receptor Complex with GRK5. Cell 169:407-421.e16 |
| Carr 3rd, Richard; Benovic, Jeffrey L (2016) From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins. Biochem Soc Trans 44:555-61 |
| Puré, Ellen; Krolikoski, Mia; Monslow, Jamie (2016) Role for Hyaluronan Synthase 3 in the Response to Vascular Injury. Arterioscler Thromb Vasc Biol 36:224-5 |
| Panettieri Jr, Reynold A (2015) Bronchodilators, receptors and cross-talk: Together is better? Postgrad Med 127:771-80 |
| Jude, Joseph A; Tirumurugaan, Krishnaswamy G; Kang, Bit Na et al. (2012) Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases. Am J Respir Cell Mol Biol 47:427-35 |
| Goncharova, Elena A; Lim, Poay N; Chisolm, Amelia et al. (2010) Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 299:L25-35 |
| Dweik, Raed A; Sorkness, Ronald L; Wenzel, Sally et al. (2010) Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 181:1033-41 |
| Lara, Abigail; Khatri, Sumita B; Wang, Zeneng et al. (2008) Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med 178:673-81 |
| Comhair, Suzy A A; Ricci, Kristin S; Arroliga, Mercedes et al. (2005) Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 172:306-13 |
