Abstract

The purposesof this Core is to begin to translate findings from experimental studies in the individual projectsexamining Angll-induced AAAs to human AAAs. Specifically, this Core will offer the following services:1. A tissue bank of human AAAs for immunohistochemical analysis of mediators under study in theindividual projects.2. Sera, plasma and DNA samples from the AAA Cohort and the Health In Men Study from the WesternAustralia Abdominal Aortic Aneurysm Study (WA AAAS). These samples will be used to examine therelationship between plasma concentrations of molecules of interest, genotypes and aortic diameter.3. Statistical analysis of serum concentrations and aortic diameter, odds ratios and 95% confidence intervalsto estimate the relative risk of either aortic diameter or rate of expansion with concentration of the mediator.4. Cardiovascular imaging to noninvasively examine AAAs and their relationship to proposed plasmameasurements.Establishment of this Core with recognized Clinician Scientists to supervise translational studies as well assamples from an NIH funded study focused on a unique AAA population will permit translation ofexperimental studies to human AAAs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL080100-01A1
Application #
7160757
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2006-04-01
Project End
2011-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$387,648
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Davis, Frank M; Rateri, Debra L; Daugherty, Alan (2015) Abdominal aortic aneurysm: novel mechanisms and therapies. Curr Opin Cardiol 30:566-73
Liu, Jing; Lu, Hong; Howatt, Deborah A et al. (2015) Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol 35:1826-34
Webb, Nancy R; De Beer, Maria C; Wroblewski, Joanne M et al. (2015) Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol 35:1156-65
Blomkalns, Andra L; Gavrila, Daniel; Thomas, Manesh et al. (2013) CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc 2:e000065
Subramanian, Venkateswaran; Moorleghen, Jessica J; Balakrishnan, Anju et al. (2013) Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One 8:e72214
Lu, Hong; Rateri, Debra L; Bruemmer, Dennis et al. (2012) Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Clin Sci (Lond) 123:531-43
Wang, Shaoping; Subramanian, Venkateswaran; Lu, Hong et al. (2012) Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms. Atherosclerosis 220:375-80
Xie, Xiaojie; Lu, Hong; Moorleghen, Jessica J et al. (2012) Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. PLoS One 7:e46411
Rateri, Debra L; Moorleghen, Jessica J; Knight, Victoria et al. (2012) Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 7:e51483
Subramanian, Venkateswaran; Golledge, Jonathan; Heywood, Elizabeth B et al. (2012) Regulation of peroxisome proliferator-activated receptor-? by angiotensin II via transforming growth factor-?1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells. Arterioscler Thromb Vasc Biol 32:397-405

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