Abstract

The staff of the Neuropathology Core will coordinate brain autopsies, dissect and store autopsy brain tissues for research and perform brain cutting, diagnostic grading and morphometric and immunocytochemical evaluation on all autopsy cases of Huntington's disease (HD) and appropriate control cases. A new computer database will be established to record clinical and pathological data on each case. This information will be available to investigators in a manner that maintains the confidentiality of patient identification. Research tissue will be used by a number of different investigators, including those in this core and in Projects 4 and 5, and for RFLP studies of genetic linkage and presymptomatic testing families. The staff of the Neuropathology Core will devise tissue dissection protocols to supply optimally prepared tissue for the different research projects. A study of neuropathological diagnosis and histopathological grading in HD will be made, oriented toward improved diagnosis in cases with minimal pathologic changes and cases with confounding lesions such as stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS016375-16A1
Application #
5215127
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Faria, Andreia V; Ratnanather, J Tilak; Tward, Daniel J et al. (2016) Linking white matter and deep gray matter alterations in premanifest Huntington disease. Neuroimage Clin 11:450-460
Krause, Amanda; Mitchell, Claire; Essop, Fahmida et al. (2015) Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype. Am J Med Genet B Neuropsychiatr Genet 168:573-85
Ross, Christopher A; Pantelyat, Alex; Kogan, Jane et al. (2014) Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction. Mov Disord 29:1351-8
Hua, Jun; Unschuld, Paul G; Margolis, Russell L et al. (2014) Elevated arteriolar cerebral blood volume in prodromal Huntington's disease. Mov Disord 29:396-401
Unschuld, Paul G; Liu, Xinyang; Shanahan, Megan et al. (2013) Prefrontal executive function associated coupling relates to Huntington's disease stage. Cortex 49:2661-73
Biglan, K M; Dorsey, E R; Evans, R V V et al. (2012) Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. J Huntingtons Dis 1:65-9
Unschuld, Paul G; Joel, Suresh E; Liu, Xinyang et al. (2012) Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease. Neurosci Lett 514:204-9
Unschuld, Paul G; Joel, Suresh E; Pekar, James J et al. (2012) Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex. Psychiatry Res 203:166-74
Aggarwal, Manisha; Duan, Wenzhen; Hou, Zhipeng et al. (2012) Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging. Neuroimage 60:2086-95
Lee, Youngjin; Morrison, Brett M; Li, Yun et al. (2012) Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 487:443-8

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