The major objective of the AIDS Dementia Center is to map the course of HIV on the nervous system, to find identifiers of the earliest neurological involvement and predictors of neurologic decline in adults and children. The activities of the Core and five Projects described projects are very closely interrelated to develop the mission of the center. The cohorts of subjects are already established. Projects are: Project 1- Detailed longitudinal evaluation of adult HIV infected subjects, with careful documentation at six month intervals of neurological, neuropsychological psychiatric, cerebrospinal fluid and hematological examination. Participation in multicenter protocols of antiretroviral agents for the prevention of the onset of neurological disease and its treatment if it does occur. A percentage of the subjects in this Project will also be evaluated in Projects 1-4) Project 2- Similar studies, without CSF, on HIV infected hemophiliac children and adolescents. Project 4- Detailed clinical neurophysiological examinations of these two cohorts, to include: routine and quantitative EEG; visual, brainstem auditory, P3 cognitive and somatosensory evoked potentials; in the adults, nerve conduction and fiber density studies. Project 5- Evaluation of the same subjects with magnetic resonance imaging and magnetic resonance spectroscopy. The objectives of the Program will be achieved by correlation of the results of the multifactorial evaluations, by using subjects as their own controls and by comparison with normal controls.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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Special Emphasis Panel (SRC (08))
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University of North Carolina Chapel Hill
Schools of Medicine
Chapel Hill
United States
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Robertson, Kevin R; Parsons, Thomas D; Rogers, Steven A et al. (2007) Assessing health-related quality of life in NeuroAIDS: some psychometric properties of the Neurological Quality of Life Questionnaire (NeuroQOL). J Clin Neurosci 14:416-23
Robertson, Kevin; Parsons, Thomas D; Van Der Horst, Charles et al. (2006) Thoughts of death and suicidal ideation in nonpsychiatric human immunodeficiency virus seropositive individuals. Death Stud 30:455-69
Inman, Tina Hanlon; Esther, Julie K; Robertson, Wendy T et al. (2002) The Minnesota Multiphasic Personality Inventory-2 across the human immunodeficiency virus spectrum. Assessment 9:24-30
Robertson, K; Fiscus, S; Kapoor, C et al. (1998) CSF, plasma viral load and HIV associated dementia. J Neurovirol 4:90-4
Corder, E H; Robertson, K; Lannfelt, L et al. (1998) HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med 4:1182-4
Hooper, S R; Whitt, J K; Tennison, M B et al. (1997) HIV-infected children with hemophilia: one- and two-year follow-up of neuropsychological functioning. Pediatr AIDS HIV Infect 8:91-7
Hall, M; Whaley, R; Robertson, K et al. (1996) The correlation between neuropsychological and neuroanatomic changes over time in asymptomatic and symptomatic HIV-1-infected individuals. Neurology 46:1697-702
Whitt, J K; Hooper, S R; Tennison, M B et al. (1993) Neuropsychologic functioning of human immunodeficiency virus-infected children with hemophilia. J Pediatr 122:52-9
Hooper, S R; Whitt, J K; Tennison, M et al. (1993) Behavioral adaptation to human immunodeficiency virus-seropositive status in children and adolescents with hemophilia. Am J Dis Child 147:541-5
Robertson, K R; Hall, C D (1992) Human immunodeficiency virus-related cognitive impairment and the acquired immunodeficiency syndrome dementia complex. Semin Neurol 12:18-27

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