CORE A. PRIMATE RESEARCH LABORATORY This Core Unit, funded through a Consortium agreement with the Axion Research Foundation, provides primates, fetal tissue, laboratory facilities, necessary equipment, and supporting staff to carry out atl of the live-animal experiments in monkeys. It has been a key component of this program since the first successful neural transplants were carried out in monkeys at this facility prior to the funding of this program. The research proposed in the three projects of this proposal requires studies in nonhuman primates in order to increase the probability that the scientific knowledge gained and the techniques developed will be applicable to the human nervous system and possible treatments of its disorders. Based on prior experience, estimated effect sizes and variability from prior experiments, and the scientific rationales described in this proposal, these studies will require a large number of monkeys and embryos of specific ages. This facility, therefore, is unique in its ability to carry out these studies at the required level, not only because of the animal resources available in a primate source country, but because of the experienced, dedicated staff and veterinarians who provide the necessary support for animal care and research data collection. Although this is a separate laboratory, the projects and experiments wilt all actually be carried out by the senior investigators of the program or under their direct supervision.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS044281-04
Application #
7553821
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
4
Fiscal Year
2006
Total Cost
$294,939
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Redmond Jr, D Eugene; McEntire, Caleb R S; Kingsbery, Joseph P et al. (2013) Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model. Mol Ther 21:2160-8
Redmond Jr, D Eugene; Evans, Lawrence (2012) Determination of fetal age by ultrasonography in St. Kitts green monkeys. Am J Primatol 74:433-41
Redmond Jr, D Eugene (2012) Using monkeys to understand and cure Parkinson disease. Hastings Cent Rep Suppl:S7-S11
DeMartelly, Victoria; Hurley, Patrick; Lawrence, Mathew et al. (2012) Comparison of fresh to fixed weights of the vervet monkey (Chlorocebus sabaeus) placenta and its relation to gestational age. J Med Primatol 41:158-62
Morrow, B A; Roth, R H; Redmond Jr, D E et al. (2012) Susceptibility to a parkinsonian toxin varies during primate development. Exp Neurol 235:273-81
Bloch, Jocelyne; Kaeser, Mélanie; Sadeghi, Yalda et al. (2011) Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development. J Comp Neurol 519:775-89
Hurley, P J; Elsworth, J D; Whittaker, M C et al. (2011) Aged monkeys as a partial model for Parkinson's disease. Pharmacol Biochem Behav 99:324-32
Morrow, B A; Roth, R H; Redmond, D E et al. (2011) Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease. Neuroscience 189:277-85
Redmond Jr, Donald Eugene; Weiss, Stephanie; Elsworth, John D et al. (2010) Cellular repair in the parkinsonian nonhuman primate brain. Rejuvenation Res 13:188-94
Markakis, Eleni A; Vives, Kenneth P; Bober, Jeremy et al. (2010) Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain. Mol Ther 18:588-93

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