SOCIAL AND BEHAVIORAL SCIENCES CORE (CORE E) Project Summary The overall mission of the Social and Behavioral Sciences (SBS) Core E is to facilitate the development and implementation of research related to the prevention, treatment, and care of HIV/AIDS that is based on or incorporates social and behavioral perspectives and is innovative, theoretically driven, methodologically rigorous, interdisciplinary, and of high impact. The Core emphasizes research based in the Washington, DC metropolitan area or with implications for the HIV/AIDS epidemic in the area.
Core specific aims i nclude: 1) Maintain a strong Core infrastructure that provides effective services in support of the development of new theoretically sound, methodologically rigorous, innovative grant applications and the implementation of funded research; 2) Ensure opportunities for networking and building collaborations both among social and behavioral scientists and between them and biomedical and clinical researchers; 3) Oversee education, training, and compilation of resources related to theory, methods, and design of social and behavioral research; and 4) Facilitate the conduct of community-engaged research that is guided by and of benefit to community needs, at the local, regional and national level.
These aims will be accomplished through the provision of a range of services, including individual and peer group consultations; Core meetings, mixers and special networking events (including across Core and with community); development and maintenance of an experts database describing substantive, theoretical and methodological expertise in the social and behavioral sciences at the CFAR, and organizational and individual expertise represented in the community; seminars, workshops, and working groups in concepts, theories, methods and methodologies in the social and behavioral sciences relevant to HIV/AIDS; and compilation of easily accessible resources related to measures, instruments, and intervention development based on SBS principles and best practices in community-engaged research. Priority in the work of the Core will be given to early stage investigators, women and underrepresented minorities, and social and behavioral scientists new to HIV/AIDS. The Core will also direct special attention to assisting investigators who are completing R01-funded research in developing their next applications. It also will provide services aimed at encouraging collaborations of SBS scientists with clinical and basic scientists to ensure SBS research includes attention to clinical and biological outcomes, and to identify innovative ways of incorporating SBS perspectives in clinical and basic science research. Finally, the Core will emphasize the development of strong relationships with community partners in the DC area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
1P30AI117970-01
Application #
8897793
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
DUNS #
043990498
City
Washington
State
DC
Country
United States
Zip Code
20052
Macedo, Amanda B; Resop, Rachel S; Martins, Laura J et al. (2018) Influence of Biological Sex, Age, and HIV Status in an In Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus. AIDS Res Hum Retroviruses 34:769-777
Calabrese, Sarah K; Earnshaw, Valerie A; Magnus, Manya et al. (2018) Sexual Stereotypes Ascribed to Black Men Who Have Sex with Men: An Intersectional Analysis. Arch Sex Behav 47:143-156
Desrosiers, Aimee; Levy, Matthew; Dright, Aurnell et al. (2018) A Randomized Controlled Pilot Study of a Culturally-Tailored Counseling Intervention to Increase Uptake of HIV Pre-exposure Prophylaxis Among Young Black Men Who Have Sex with Men in Washington, DC. AIDS Behav :
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Houzet, Laurent; PĂ©rez-Losada, Marcos; Matusali, Giulia et al. (2018) Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs. J Virol 92:
Macedo, Amanda B; Novis, Camille L; De Assis, Caroline M et al. (2018) Dual TLR2 and TLR7 agonists as HIV latency-reversing agents. JCI Insight 3:
Ren, Yanqin; Korom, Maria; Truong, Ronald et al. (2018) Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs. J Virol 92:
Orekhov, Alexander N; Pushkarsky, Tatiana; Oishi, Yumiko et al. (2018) HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages. Exp Mol Pathol 105:202-207
Huang, Szu-Han; Ren, Yanqin; Thomas, Allison S et al. (2018) Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells. J Clin Invest 128:876-889
Adzhubei, Alexei A; Anashkina, Anastasia A; Tkachev, Yaroslav V et al. (2018) Modelling interaction between HIV-1 Nef and calnexin. AIDS 32:2103-2111

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