The Mechanical and Material Assessment Core focuses on providing complementary techniques for determining mechanical properties and performing material characterization of native and engineered orthopaedic tissues, as well as providing in vivo models to study adaptation of these skeletal tissues to mechanical stimuli. Skeletal tissues include bone, cartilage, ligament, menicus and tendon, and accomplish their in vivo function through a wide range of material compositions and mechanical behavior. These tissues are responsive to their biophysical and biochemical environments, adapting their composition and structure. Skeletal function is dictated by the properties of the materials and the spatial distribution of the materials within the structure. Assessing function is fundamental to endeavors aimed at musculoskeletal repair and regeneration, because these attempts will only succeed if mechanical function can be restored. Therefore, the goals of the Mechanical and Material Assessment Core are to provide equipment and methodologies for mechanical testing and material characterization of musculoskeletal tissues and organs;to train investigators in the use and interpretation of these techniques;and, to develop new applications and methodologies to support the research programs of investigators within the Core Center's biomedical research base. New testing methodologies suitable to the biological approaches being used in current and planned experiments by cOre investigators have been developed, particularly for in vivo small animal experiments, to complement techniques (such as micro-CT, histology, and Fourier transform infrared imaging) available in the Center's other research cores. These efforts are periodically reviewed by user groups, which include biomedical engineers, clinicians, biologists, radiologists, chemists, and their students. The result has been an expansion of collaborations among the multidisciplinary biomedical research base and the introduction of new investigators to the capabilities of the core.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Hospital for Special Surgery
New York
United States
Zip Code
Qu, Dovina; Subramony, Siddarth D; Boskey, Adele L et al. (2017) Compositional mapping of the mature anterior cruciate ligament-to-bone insertion. J Orthop Res 35:2513-2523
Ishack, Stephanie; Mediero, Aranzazu; Wilder, Tuere et al. (2017) Bone regeneration in critical bone defects using three-dimensionally printed ?-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2. J Biomed Mater Res B Appl Biomater 105:366-375
Yang, Haisheng; Albiol, Laia; Chan, Wing-Lee et al. (2017) Examining tissue composition, whole-bone morphology and mechanical behavior of GorabPrx1 mice tibiae: A mouse model of premature aging. J Biomech 65:145-153
Foster, B L; Kuss, P; Yadav, M C et al. (2017) Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia. J Dent Res 96:81-91
Mediero, Aránzazu; Wilder, Tuere; Ramkhelawon, Bhama et al. (2016) Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis. FASEB J 30:3835-3844
Mediero, Aránzazu; Ramkhelawon, Bhama; Wilder, Tuere et al. (2016) Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis. Ann Rheum Dis 75:1706-13
Mediero, Aránzazu; Wilder, Tuere; Reddy, Vishnu S R et al. (2016) Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism. FASEB J 30:3887-3900
Masci, Marco; Wang, Min; Imbert, Laurianne et al. (2016) Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta. Bone 87:120-9
Holyoak, Derek T; Tian, Ye F; van der Meulen, Marjolein C H et al. (2016) Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment. Ann Biomed Eng 44:2062-75
Grosso, Matthew J; Courtland, Hayden-William; Yang, Xu et al. (2015) Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone. J Orthop Res 33:163-73

Showing the most recent 10 out of 195 publications