The research of the McArdle Laboratory for Cancer Research is divided into three broad categories: Biochemical Studies in Chemical Carcinogenesis, Molecular Biology and Genetics of Tumor Viruses, and The Cell Cycle and Differentiation in Tumor Biology. The chemical carcinogenesis program encompasses a broad fundamental a approach to the chemistry, biochemistry, and biology of mutation, tumor initiation, and tumor promotion due to chemicals. These projects include studies on the genetic control of initiation and promotion, the biochemical regulation of enzyme activities, the metabolic activation of carcinogens, the characterization of cellular receptors for tumor promoters, and the analysis of preneoplastic lesions. The studies in tumor virology encompass the molecular biology and genetics of avian and murine RNA tumor viruses and of three primate DNA tumor viruses, simian virus 40, papillomaviruses, and Epstein-Barr virus. This tumor virology program approaches problems of the identification of viral genes responsible for cancer, their mechanisms of transformation and control of tissue specificity, the mechanisms of integration or maintenance of viral genomes, the control of expression of viral genes, and the con- struction and properties of vectors based on tumor viruses. The tumor biology program is a multidisciplinary approach to the elucidation of regulatory mechanisms that influence the growth, replication, and differentiation of normal and cancer cells. For instance, this program examines factors affecting the transcription of specific genes and the role of RNA structure in its intracellular-localization, stability, and expres- sion. The importance of cell membranes for cell replication control and immune recognition, as well as for the regulation of cell differentiation, are being investigated in a range of eukaryotic systems. Integral to the objectives and aims of the McArdle Laboratory is research training at the pre- and postdoctoral levels in the general area of the cell and molecular biology of neoplasia and carcinogenesis. Approximately 100 individuals are presently receiving such training in the McArdle Laboratory, and more than 700 have received research training in these areas in the McArdle Laboratory in the past.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Cancer Center Support Review Committee (CCS)
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University of Wisconsin Madison
Internal Medicine/Medicine
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United States
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Thompson, Nancy E; Glaser, Bryan T; Foley, Katherine M et al. (2009) Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. J Biol Chem 284:24754-66
Habig, Jeffrey W; Loeb, Daniel D (2006) Sequence identity of the direct repeats, DR1 and DR2, contributes to the discrimination between primer translocation and in situ priming during replication of the duck hepatitis B virus. J Mol Biol 364:32-43
Liu, Ning; Ji, Lin; Maguire, Megan L et al. (2004) cis-Acting sequences that contribute to the synthesis of relaxed-circular DNA of human hepatitis B virus. J Virol 78:642-9
Tessier, Charles R; Doyle, Glenn A; Clark, Brad A et al. (2004) Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 64:209-14
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Habig, Jeffrey W; Loeb, Daniel D (2003) Template switches during plus-strand DNA synthesis of duck hepatitis B virus are influenced by the base composition of the minus-strand terminal redundancy. J Virol 77:12412-20
Habig, Jeffrey W; Loeb, Daniel D (2003) The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus. J Virol 77:12401-11
Bunger, Maureen K; Moran, Susan M; Glover, Edward et al. (2003) Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278:17767-74
Liu, Ning; Tian, Ru; Loeb, Daniel D (2003) Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription. Proc Natl Acad Sci U S A 100:1984-9
Mueller-Hill, Karlyn; Loeb, Daniel D (2002) cis-Acting sequences 5E, M, and 3E interact to contribute to primer translocation and circularization during reverse transcription of avian hepadnavirus DNA. J Virol 76:4260-6

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