Researchers from 13 Sections, Laboratories, or Branches have used the Facility during the past year and 21 researchers have been newly trained to use one or several of the instruments. As always, LIS staff have assisted already trained Facility users to get familiar with the more demanding techniques such as TIRF, to improve the quality of their images, and to prepare these images for publication. NIAMS publications which have benefited from such help and/ or show images collected on our instruments are listed in the bibliography. Microscopy done in LIS in the past year has contributed to expand knowledge in several NIAMS research target areas: i) understanding the immune system and its diseases (Suzuki et al, 2010); ii) understanding skin development and diseases (Duverger et al., 2011;Hwang et al., 2011); iii) understanding muscle development (Juan et al., 2011) and muscle diseases (Raben et al., 2010 a and b;Takikita et al, 2010;Xu et al, 2010). The reach of the microscopy techniques available to NIAMS researchers has been expanded by the addition of a new objective lens, the Leica 25x 1.0, a high numerical aperture, long working distance objective that is particularly useful for intravital microscopy. Facility Staff have demonstrated the use of microscopy techniques and their applications to NIAMS target areas during a visit by a delegation of Congressional Aides and a visit by the Academy of Orthopedic Surgeons, during which orthopedic patients and their physicians toured the Facility.
| Thumbigere-Math, V; Alqadi, A; Chalmers, N I et al. (2018) Hypercementosis Associated with ENPP1 Mutations and GACI. J Dent Res 97:432-441 |
| Lim, Jeong-A; Sun, Baodong; Puertollano, Rosa et al. (2018) Therapeutic Benefit of Autophagy Modulation in Pompe Disease. Mol Ther 26:1783-1796 |
| Madsen, Agnete B; Knudsen, Jonas R; Henriquez-Olguin, Carlos et al. (2018) ?-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle. Am J Physiol Endocrinol Metab 315:E110-E125 |
| Ferdinand, John R; Richard, Arianne C; Meylan, Françoise et al. (2018) Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol 200:1360-1369 |
| Duverger, Olivier; Morasso, Maria I (2018) Pleiotropic function of DLX3 in amelogenesis: from regulating pH and keratin expression to controlling enamel rod decussation. Connect Tissue Res 59:30-34 |
| Navid, Fatemeh; Layh-Schmitt, Gerlinde; Sikora, Keith A et al. (2018) The Role of Autophagy in the Degradation of Misfolded HLA-B27 Heavy Chains. Arthritis Rheumatol 70:746-755 |
| Duverger, Olivier; Cross, Michael A; Smith, Frances J D et al. (2018) Enamel anomalies in a pachyonychia congenita patient with a mutation in KRT16. J Invest Dermatol : |
| Iglesias-Bartolome, Ramiro; Uchiyama, Akihiko; Molinolo, Alfredo A et al. (2018) Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med 10: |
| Sarshad, Aishe A; Juan, Aster H; Muler, Ana Iris Correa et al. (2018) Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells. Mol Cell : |
| Duverger, Olivier; Carlson, Jenna C; Karacz, Chelsea M et al. (2018) Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay. PLoS Genet 14:e1007168 |
Showing the most recent 10 out of 81 publications
