Researchers from 13 Sections, Laboratories, or Branches have used the Facility during the past year and 21 researchers have been newly trained to use one or several of the instruments. As always, LIS staff have assisted already trained Facility users to get familiar with the more demanding techniques such as TIRF, to improve the quality of their images, and to prepare these images for publication. NIAMS publications which have benefited from such help and/ or show images collected on our instruments are listed in the bibliography. Microscopy done in LIS in the past year has contributed to expand knowledge in several NIAMS research target areas: i) understanding the immune system and its diseases (Suzuki et al, 2010); ii) understanding skin development and diseases (Duverger et al., 2011;Hwang et al., 2011); iii) understanding muscle development (Juan et al., 2011) and muscle diseases (Raben et al., 2010 a and b;Takikita et al, 2010;Xu et al, 2010). The reach of the microscopy techniques available to NIAMS researchers has been expanded by the addition of a new objective lens, the Leica 25x 1.0, a high numerical aperture, long working distance objective that is particularly useful for intravital microscopy. Facility Staff have demonstrated the use of microscopy techniques and their applications to NIAMS target areas during a visit by a delegation of Congressional Aides and a visit by the Academy of Orthopedic Surgeons, during which orthopedic patients and their physicians toured the Facility.

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National Institute of Arthritis and Musculoskeletal and Skin Diseases
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Iglesias-Bartolome, Ramiro; Uchiyama, Akihiko; Molinolo, Alfredo A et al. (2018) Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med 10:
Sarshad, Aishe A; Juan, Aster H; Muler, Ana Iris Correa et al. (2018) Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells. Mol Cell :
Duverger, Olivier; Carlson, Jenna C; Karacz, Chelsea M et al. (2018) Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay. PLoS Genet 14:e1007168
Feng, Li Rebekah; Fernández-Martínez, Juan Luis; Zaal, Kristien J M et al. (2018) mGluR5 mediates post-radiotherapy fatigue development in cancer patients. Transl Psychiatry 8:110
Lee, Jeansun; Dieckmann, Nele M G; Edgar, James R et al. (2018) Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse. Immun Inflamm Dis 6:312-321
Wolf, M; Ao, M; Chavez, M B et al. (2018) Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis. J Dent Res 97:937-945
Gupta, Sarthak; Chan, Diana W; Zaal, Kristien J et al. (2018) A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils. J Immunol 200:869-879
Thumbigere Math, V; Rebouças, P; Giovani, P A et al. (2018) Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response. JDR Clin Trans Res 3:35-46
Bhattacharya, Shreya; Kim, Jin-Chul; Ogawa, Youichi et al. (2018) DLX3-Dependent STAT3 Signaling in Keratinocytes Regulates Skin Immune Homeostasis. J Invest Dermatol 138:1052-1061
Sikora, Keith A; Bennett, Joshua R; Vyncke, Laurens et al. (2018) Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis. J Allergy Clin Immunol 141:1943-1947.e9

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