Community Outreach and Engagement ABSTRACT The City of Hope Comprehensive Cancer Center (COHCCC) is a freestanding cancer center whose main campus is located in Duarte, California. The COHCCC Catchment Area includes the entirety of Los Angeles and Orange Counties and portions of Ventura, Riverside, and San Bernardino Counties. The Catchment Area is bounded by the Pacific Ocean to the south and west; Antelope Valley to the north; Santa Clarita and Simi Valley to the west; the metropolitan areas of Riverside and San Bernardino to the east; and the communities of Palm Desert, Murrieta, and San Clemente to the south. The COHCCC Catchment Area covers 9,365 square miles and includes the heart of the greater Los Angeles metropolitan area and more inland communities. We serve a multi-racial, multi-ethnic community of over 17.1 million individuals, which represents approximately 40 percent of all Californians. Remarkably, the population of our Catchment Area is greater than the individual populations of 46 states and greater than the populations of 14 states combined. The COHCCC seeks to use its research and resources to improve the lives of the men, women, and children who live in our Catchment Area, particularly in the more inland regions. The residents we serve face challenges that impact cancer survival, including poverty, obesity, and lack of access. These challenges are uniformly faced whether an individual comes from urban or more rural environments. To achieve this goal, COHCCC has three themes: 1. Identify and pursue challenging questions in cancer research relevant to the people of our Catchment Area. 2. Develop and implement strategies for including underserved populations in our programmatic research. 3. Take advantage of research discoveries, collaborations, networks, and affiliates to extend our reach and to implement creative interventions to increase access and health equity within our Catchment Area, as well as nationally and internationally. To reduce the incidence of cancer in the unique populations we serve within our Catchment Area, we identified the following priorities: ? Biologically aggressive cancers that impact diverse populations in our COHCCC Catchment Area ? Viral-related cancers, including hepatocellular carcinoma and HIV-related malignancies ? Impact of pollution on cancer incidence, with a focus on breast and lung cancer ? Cancers of aging in Asian- and Latino-Americans

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA033572-35
Application #
9491639
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-20
Budget End
2018-11-30
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Li, Daneng; McCall, Linda M; Hahn, Olwen M et al. (2018) Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study. Breast Cancer Res Treat 171:325-334
Aslamy, Arianne; Oh, Eunjin; Ahn, Miwon et al. (2018) Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes. J Clin Endocrinol Metab 103:1966-1976
Abeywardana, Tharindumala; Oh, Myungeun; Jiang, Lei et al. (2018) CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. J Biol Chem 293:15290-15303
Sun, Virginia; Crane, Tracy E; Slack, Samantha D et al. (2018) Rationale, development, and design of the Altering Intake, Managing Symptoms (AIMS) dietary intervention for bowel dysfunction in rectal cancer survivors. Contemp Clin Trials 68:61-66
Herrera, A F; Palmer, J; Martin, P et al. (2018) Autologous stem-cell transplantation after second-line brentuximab vedotin in relapsed or refractory Hodgkin lymphoma. Ann Oncol 29:724-730
Caserta, Enrico; Chea, Junie; Minnix, Megan et al. (2018) Copper 64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma. Blood 131:741-745
Smith, Nicholas R; Swain, John R; Davies, Paige S et al. (2018) Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations. Cell Mol Gastroenterol Hepatol 6:79-96
Jandial, Rahul; Neman, Josh; Lim, Punnajit P et al. (2018) Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. Int J Mol Sci 19:
Zhou, Jiehua; Lazar, Daniel; Li, Haitang et al. (2018) Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1. Theranostics 8:1575-1590
Salgia, Ravi; Kulkarni, Prakash; Gill, Prakash S (2018) EphB4: A promising target for upper aerodigestive malignancies. Biochim Biophys Acta Rev Cancer 1869:128-137

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