The goal of the Cell & Molecular Biology (CMB) Core is to enhance and extend the quality and scope ofindividual research projects, by providing access to molecular technologies and measures that will yieldinsights into the molecular basis for hearing and hearing impairment. To achieve this goal the CMB Corehas Specific Aims that fall into four areas: Development, Education, Collaboration and Service. InDevelopment, the CMB will bring new methods and approaches to individual investigators and developtechnology and data bases to facilitate use of the mouse model. In Education, the CMB will provideinformation on new advances in methodology to individual investigators, train staff of individual investigatorsin both routine and novel molecular methodologies, provide a bridge to centralized University of Michiganfacilities for novel and advanced methodologies, and hold monthly meetings of Core Discussion Group withoutside experts on specific topics to introduce new methods and approaches, share experiences, problemsand successes and develop new productive collaborations. This last goal will be expanded InCollaborations, in which the CMB will bring new investigators to the study of hearing and balance research,bring in outside experts for new directions and approaches, and provide a format for discussions leading tonew areas and directions of research. For Service, the CMB will provide state-of-the-art support formorphological and molecular assessments, provide assistance in integration of morphological and molecularassessments, provide normative data bases and provide assistance in experimental design andinterpretation of results.The CMB Core will also work closely with the Physiology Core and the Delivery Core to coordinatephysiological and morphological characterization of animals at both the molecular and systems level toenhance our understanding of hearing and to define molecular interventions that will prevent and treathearing loss.
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