Although cochlear implants (CI) can dramatically improve speech recognition for many patients in quiet surroundings, CI performance and outcome is variable across individuals;speech recognition in noise is often worse, and music perception is not improved. The purpose for this application is to recruit a young investigator with recognized talent and potential to develop a translational research program in an academic otolaryngology department with a large clinical cochlear implant program and strong history for neuro-otologic basic science research. The ultimate goal of this program is to improve outcomes in cochlear implant patients. The research goals outlined in this application are threefold. The first project will focus on identifying the mechanisms affecting change in pitch perception over time in CI patients, and how the changes affect CI performance. The second project is to improve speech perception and optimize the interaction between the acoustic and electric hearing in CI patients with residual hearing. The third project will address preservation of residual hearing with cochlear implantation. As mechanisms for preservation of hearing are identified and tested in animal models, these methodologies will be developed and translated to human studies. The individual identified for this program, Lina Reiss, Ph.D. provides a unique opportunity for multidisciplinary collaboration because of her training in both clinical and engineering aspects of CI technology, and her background in processing within auditory brainstem circuits. As a result, she speaks several """"""""languages"""""""", and provides a key link between different aspects of the research community. The addition of Dr. Reiss will add a new dimension to the core center with a strong translational component focusing on optimizing cochlear implantation;thus, opening doors for collaboration not previously realized.

Public Health Relevance

The cochlear implant (CI) is the most successful neural prosthesis with over 35,000 children and adults implanted in the United States. Although CIs can dramatically improve speech recognition, for many patients the outcome is variable, and under certain conditions may be worse. The primary goal of this program is to develop strategies to improve these outcomes in CI patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC010755-02
Application #
7933785
Study Section
Special Emphasis Panel (ZDC1-SRB-L (43))
Program Officer
Davis, Barry
Project Start
2009-09-17
Project End
2012-06-30
Budget Start
2010-09-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$690,260
Indirect Cost
Name
Oregon Health and Science University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Reiss, Lina A J; Fowler, Jennifer R; Hartling, Curtis L et al. (2018) Binaural Pitch Fusion in Bilateral Cochlear Implant Users. Ear Hear 39:390-397
Reiss, Lina A J; Shayman, Corey S; Walker, Emily P et al. (2017) Binaural pitch fusion: Comparison of normal-hearing and hearing-impaired listeners. J Acoust Soc Am 141:1909
Fowler, Jennifer R; Eggleston, Jessica L; Reavis, Kelly M et al. (2016) Effects of Removing Low-Frequency Electric Information on Speech Perception With Bimodal Hearing. J Speech Lang Hear Res 59:99-109
Reiss, Lina A J; Eggleston, Jessica L; Walker, Emily P et al. (2016) Two Ears Are Not Always Better than One: Mandatory Vowel Fusion Across Spectrally Mismatched Ears in Hearing-Impaired Listeners. J Assoc Res Otolaryngol 17:341-56
Reiss, Lina A J; Stark, Gemaine; Nguyen-Huynh, Anh T et al. (2015) Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model. Hear Res 327:163-74
Reiss, Lina A J; Ito, Rindy A; Eggleston, Jessica L et al. (2015) Pitch adaptation patterns in bimodal cochlear implant users: over time and after experience. Ear Hear 36:e23-34
Zhang, Hongzheng; Stark, Gemaine; Reiss, Lina (2015) Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation. Otol Neurotol 36:1157-65
Tanaka, Chiemi; Nguyen-Huynh, Anh; Loera, Katherine et al. (2014) Factors associated with hearing loss in a normal-hearing guinea pig model of Hybrid cochlear implants. Hear Res 316:82-93
Reiss, Lina A J; Ito, Rindy A; Eggleston, Jessica L et al. (2014) Abnormal binaural spectral integration in cochlear implant users. J Assoc Res Otolaryngol 15:235-48