The Gnotobiotics, Microbiology and Metagenomics Core (Core D), aims to identify the causal relationships between our colonizing microbiota and host health and disease, both in human clinical trials and in animal models. Core D supports more than 50 groups interested in evaluating mechanisms by which the host's microbiota affects health and disease, with particular focus to define functional effects of microbial communities in vivo. Our resources include an Intake Unit to handle logistics for sample and data collection, a Molecular Unit for sequence-based analyses, Microbiology Unit to analyze primary samples and manipulate isolates for functional studies, a Gnotobiotic (germfree) mouse facility for in vivo studies in animal models, and Computational Unit which includes bioinformatics and computational support, including access to computational clusters and personnel for assisting in experimental design and analysis of complex metagenomic datasets. As a core we provide support to nearly all academic centers in the greater Boston area.
| Kasendra, Magdalena; Tovaglieri, Alessio; Sontheimer-Phelps, Alexandra et al. (2018) Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep 8:2871 |
| Wilen, Craig B; Lee, Sanghyun; Hsieh, Leon L et al. (2018) Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science 360:204-208 |
| Rodriguez-Fraticelli, Alejo E; Wolock, Samuel L; Weinreb, Caleb S et al. (2018) Clonal analysis of lineage fate in native haematopoiesis. Nature 553:212-216 |
| Franz, Kate M; Neidermyer, William J; Tan, Yee-Joo et al. (2018) STING-dependent translation inhibition restricts RNA virus replication. Proc Natl Acad Sci U S A 115:E2058-E2067 |
| Brown, Jonathan D; Feldman, Zachary B; Doherty, Sean P et al. (2018) BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A 115:2144-2149 |
| Dumontet, Typhanie; Sahut-Barnola, Isabelle; Septier, Amandine et al. (2018) PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight 3: |
| Jirapinyo, Pichamol; Thompson, Andrew C; Kröner, Paul T et al. (2018) Metabolic Effect of Foregut Exclusion Demonstrated by the Impact of Gastrogastric Fistula on Recurrence of Diabetes. J Am Coll Surg 226:259-266.e1 |
| Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4 |
| Schulman, Allison R; Kumar, Nitin; Thompson, Christopher C (2018) Transoral outlet reduction: a comparison of purse-string with interrupted stitch technique. Gastrointest Endosc 87:1222-1228 |
| Khandekar, Melin J; Banks, Alexander S; Laznik-Bogoslavski, Dina et al. (2018) Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A 115:561-566 |
Showing the most recent 10 out of 869 publications
