The Bioinformatics Core was established in 2007 to provide analytical support for numerous research projects at the Joslin Diabetes Center. Core activities and resources including biostatistics consulting, the clinical data warehouse, the high-performance computer cluster and the analysis of genomic data have benefited most labs at Joslin. The recent emergence of new technologies for high-throughput DNA sequencing, metabolomics, and proteomics among others catalyzed transformative changes throughout the biomedical sciences. The need to introduce these whole genome technologies into diabetes research brings numerous informatics and systems biology challenges. Computational science, network modeling and informatics play important roles in meeting these challenges. We propose an expanded Computational Core that will significantly enhance our analytic capabilities in order to cover not only basic support functions but also to promote innovative network modeling and systems biology approaches to diabetes research at Joslin and throughout the Boston area. The proposed Core is named the Boston University Joslin Regional Computational Core (BUJRC Core) and will consist of two branches: the Bioinformatics / Computational Biology Service branch and the Collaborative Systems Biology/Medicine branch. The Bioinformatics / Computational Biology Service branch will act as a resource to the diabetes research community by providing state-of the-art analysis of high-throughput biomedical data, as well as consultation on the design of these types of experiments. This branch will support diabetes research in the design, analysis, and biological interpretation of experiments that involve generation of omic data and its integration with physiological and clinical data. The Collaborative Systems Biology/Medicine branch will help to create an environment that incorporates computational systems biology/medicine methodologies into clinically relevant translational and basic diabetes research. This branch includes local faculty with a proven track record of having worked together to produce innovative systems biology and translational research. This proposed expanded Core will significantly enhance the prior capabilities to provide support functions to Joslin researchers as well as developing relevant network modeling and systems biology methodologies at Boston University. The expanded core will serve as a bridge for establishing collaborations with other diabetes researchers throughout the region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
4P30DK036836-30
Application #
9102063
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
30
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
Rabiee, Atefeh; Krüger, Marcus; Ardenkjær-Larsen, Jacob et al. (2018) Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. Cell Signal 47:1-15
Cai, Weikang; Xue, Chang; Sakaguchi, Masaji et al. (2018) Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest 128:2914-2926
Nowak, Natalia; Skupien, Jan; Smiles, Adam M et al. (2018) Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development. Kidney Int 93:1198-1206
Aguayo-Mazzucato, Cristina; Lee Jr, Terence B; Matzko, Michelle et al. (2018) T3 Induces Both Markers of Maturation and Aging in Pancreatic ?-Cells. Diabetes 67:1322-1331
Bartelt, Alexander; Widenmaier, Scott B; Schlein, Christian et al. (2018) Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med 24:292-303
Fujisaka, Shiho; Avila-Pacheco, Julian; Soto, Marion et al. (2018) Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell Rep 22:3072-3086
Van Name, Michelle A; Hilliard, Marisa E; Boyle, Claire T et al. (2018) Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes. Pediatr Diabetes 19:114-120
Weisman, Alanna; Lovblom, Leif E; Keenan, Hillary A et al. (2018) Diabetes Care Disparities in Long-standing Type 1 Diabetes in Canada and the U.S.: A Cross-sectional Comparison. Diabetes Care 41:88-95
Panduro, Marisella; Benoist, Christophe; Mathis, Diane (2018) Treg cells limit IFN-? production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proc Natl Acad Sci U S A 115:E2585-E2593
McGill, Dayna E; Volkening, Lisa K; Pober, David M et al. (2018) Depressive Symptoms at Critical Times in Youth With Type 1 Diabetes: Following Type 1 Diabetes Diagnosis and Insulin Pump Initiation. J Adolesc Health 62:219-225

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