Abstract

SCI Testing Paradigms: Gross locomotor skill will be assessed during open field walking with the 21-point Basso, Beattie and Bresnahan (BBB) locomotor recovery scale. The horizontal ladder (Columbus Instruments) will be used to examine hindlimb locomotor function and interlimb coordination. Specific kinetic and kinematic parameters of overground locomotion will be studied and analyzed using a runway device previously described (Muir et al. 1996; Muir and Whishaw 1999). For assessment of sensory function animals will be examined using von Frey hairs for testing tactile sensation and Hargreaves' test for nociception (Stoelting Instruments). The grip strength meter (TSE Systems) is a recently developed apparatus that measures the gripping strength of the front or hind paw of either rats or mice. Blood pressure monitors (Columbus Instruments) will also be required in order to study changes in blood pressure and heart rate in a model of autonomic dysreflexia. TBI Testing Paradigms: The Morris water maze is a well accepted procedure for studying functional deficits and recovery of function following TBI and one room of the Core will be dedicated. Animals will also be tested on additional paradigms including the rotarod test (Columbus Instruments), balance beam, and the grip strength meter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS051220-02
Application #
7312845
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$82,699
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Keeney, Jeriel T R; Ren, Xiaojia; Warrier, Govind et al. (2018) Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (""chemobrain""). Oncotarget 9:30324-30339
Sama, Diana M; Carlson, Shaun W; Joseph, Binoy et al. (2018) Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury. Restor Neurol Neurosci 36:559-569
Lanzillotta, Chiara; Tramutola, Antonella; Meier, Shelby et al. (2018) Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models. J Alzheimers Dis 62:347-359
Patel, Samir P; Cox, David H; Gollihue, Jenna L et al. (2017) Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery. Exp Neurol 293:74-82
Gensel, John C; Kopper, Timothy J; Zhang, Bei et al. (2017) Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. Sci Rep 7:40144
Orr, Michael B; Simkin, Jennifer; Bailey, William M et al. (2017) Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury. J Neurotrauma 34:2342-2352
Kulbe, Jacqueline R; Hall, Edward D (2017) Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology. Prog Neurobiol 158:15-44
Gollihue, Jenna L; Patel, Samir P; Mashburn, Charlie et al. (2017) Optimization of mitochondrial isolation techniques for intraspinal transplantation procedures. J Neurosci Methods 287:1-12
Hill, Rachel L; Singh, Indrapal N; Wang, Juan A et al. (2017) Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury. Neurochem Int 111:45-56
Zhang, Bei; Bailey, William M; McVicar, Anna Leigh et al. (2016) Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury. Neurobiol Aging 47:157-167

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