Abstract

Through Dissemination Core activities, the Washington University (WU) Biomedical Mass Spectrometry (MS) Resource achieves the fundamental goal of sharing, distributing, providing access and technical support for MS technology and software with the broad research community. The Dissemination Core will accomplish this goal by sharing, distributing, and hosting many broad outreach programs focused on MS and related technologies developed in the Resource, including: an informative website with tutorials and distance learning modules; peer-reviewed publications, reviews, books and special editions of technical journals; press releases; conference, symposia, seminar, and workshop presentations; software; and instruments, technology, and methods shared directly with other laboratories and industry.

Public Health Relevance

-Public Health Relevance. The Washington University Biomedical Mass Spectrometry Resource has a longstanding history as an active and productive citizen in the NIH Biotechnology Research Resources community. We propose to extend our mission by advancing mass spectrometry technology, development, and research, applying these discoveries to answer critical biomedical research questions, and training the next generation of researchers, towards the ultimate goal of improving public health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103422-40
Application #
9199432
Study Section
Special Emphasis Panel (ZRG1-IMST-B)
Project Start
Project End
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
40
Fiscal Year
2017
Total Cost
$69,662
Indirect Cost
$23,982

  Institution

Name
Washington University
Department
Type
Domestic Higher Education
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Zhang, Mengru Mira; Rempel, Don L; Gross, Michael L (2018) A Fast Photochemical Oxidation of Proteins (FPOP) platform for free-radical reactions: the carbonate radical anion with peptides and proteins. Free Radic Biol Med 131:126-132
Shen, G; Li, S; Cui, W et al. (2018) Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition. J Thromb Haemost 16:1164-1175
Lu, Yue; Goodson, Carrie; Blankenship, Robert E et al. (2018) Primary and Higher Order Structure of the Reaction Center from the Purple Phototrophic Bacterium Blastochloris viridis: A Test for Native Mass Spectrometry. J Proteome Res 17:1615-1623
Fernandez, Estefania; Kose, Nurgun; Edeling, Melissa A et al. (2018) Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus. MBio 9:
Johnson, Britney; VanBlargan, Laura A; Xu, Wei et al. (2018) Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity 48:487-499.e5
Girard, T J; Grunz, K; Lasky, N M et al. (2018) Re-evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology. J Thromb Haemost 16:2246-2257
Hsu, Fong-Fu (2018) Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem 410:6387-6409
Hung, Putzer J; Johnson, Britney; Chen, Bo-Ruei et al. (2018) MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell 71:332-342.e8
Illes-Toth, Eva; Rempel, Don L; Gross, Michael L (2018) Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of ?-Synuclein, the Causative Agent for Parkinson's Disease. ACS Chem Neurosci 9:1469-1476
Johnston, Adam B; Hilton, Denise M; McConnell, Patrick et al. (2018) A novel mode of capping protein-regulation by twinfilin. Elife 7:

Showing the most recent 10 out of 323 publications