The Center on Membrane Protein Production and Analysis (COMPP) has chosen 15 DBPs, which will provide a driving force for each of the TR&Ds. We use this section to describe the DBP investigators, the basis of their selection, and outline their interaction with TR&Ds. Ten of the 15 DBPs are presented in detail; detailed descriptions for the five others are provided in the Appendix.
Each Aim of each TR&D has at least three subscribed DBPs. DBPs chosen represent specific technological roadblocks that are generally acknowledged in the field. We will refine our methodologies and technologies by working towards surpassing these roadblocks. Solving these problems will produce results that, in turn, open up new biological questions. These questions will, in turn, pose new technical challenges in their solution, starting a new round of technology development.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM116799-05
Application #
9939559
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
New York Structural Biology Center
Department
Type
DUNS #
011191520
City
New York
State
NY
Country
United States
Zip Code
10027
Hartel, Andreas J W; Ong, Peijie; Schroeder, Indra et al. (2018) Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes. Proc Natl Acad Sci U S A 115:E1789-E1798
Blackburn, Matthew R; Hubbard, Caitlin; Kiessling, Volker et al. (2018) Distinct reaction mechanisms for hyaluronan biosynthesis in different kingdoms of life. Glycobiology 28:108-121
Zhang, Yu; Kittredge, Alec; Ward, Nancy et al. (2018) ATP activates bestrophin ion channels through direct interaction. Nat Commun 9:3126
Assur Sanghai, Zahra; Liu, Qun; Clarke, Oliver B et al. (2018) Structure-based analysis of CysZ-mediated cellular uptake of sulfate. Elife 7:
Su, Min; Gao, Feng; Yuan, Qi et al. (2017) Structural basis for conductance through TRIC cation channels. Nat Commun 8:15103
Dufrisne, Meagan Belcher; Petrou, Vasileios I; Clarke, Oliver B et al. (2017) Structural basis for catalysis at the membrane-water interface. Biochim Biophys Acta Mol Cell Biol Lipids 1862:1368-1385
Liu, Qun; Hendrickson, Wayne A (2017) Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis. Methods Mol Biol 1607:377-399
Scaglione, Antonella; Montemiglio, Linda Celeste; Parisi, Giacomo et al. (2017) Subcellular localization of the five members of the human steroid 5?-reductase family. Biochim Open 4:99-106
Hirschi, Marscha; Johnson, Zachary Lee; Lee, Seok-Yong (2017) Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature 545:66-70
Clarke, Oliver B; Hendrickson, Wayne A (2016) Structures of the colossal RyR1 calcium release channel. Curr Opin Struct Biol 39:144-152

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