Our goal is to develop a plan for administration and management to ensure that the biotechnology research resource operates productively and efficiently. We propose a clear organizational structure that encourages collaboration within and between technology development teams to drive rapid progress in technology development, DBPs, and community engagement efforts. We refine our established protocols for evaluating and selecting collaboration, service and driving biomedical projects. We propose an External Advisory Committee composition that will provide the expertise needed to provide advice and guidance across the full range of BTRR activities. We develop a sustainability plan to ensure that our technology persists beyond the lifetime of the resource.