Abstract

The primary goal of these studies is to ascertain the role of brain nicotinic receptors in regulating sensitivity to nicotine. Previous studies from our laboratory have demonstrated that inbred mouse strains differ extensively in the development of behavioral and physiological tolerance to nicotine. Chronic administration of nicotine increases the number of brain nicotinic receptors. In a strain of mouse that develops profound tolerance to nicotine, the dose response for receptor up-regulation differs extensively across brain regions. Current studies will determine the relationship between receptor up-regulation and tolerance development in strains of mice that develop little, if any, tolerance to nicotine. These studies may elucidate the neurobiological substrates that are responsible for the expression of tolerance to nicotine. The objective of the collaboration with the Resource is to develop a tool to assist us in rapidly analyzing the large amount of data produced as part of this study. To that end, we are constructing a 3D probability atlas of the mouse brain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001638-11
Application #
5223494
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ivey, Richard G; Subramanian, Oby; Lorentzen, Travis D et al. (2009) Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. Radiat Res 171:549-61
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Komisaruk, B R; Rosenblatt, J S; Barona, M L et al. (2000) Combined c-fos and 14C-2-deoxyglucose method to differentiate site-specific excitation from disinhibition: analysis of maternal behavior in the rat. Brain Res 859:262-72
Libon, D J; Bogdanoff, B; Cloud, B S et al. (1998) Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. J Clin Exp Neuropsychol 20:30-41
Del Cerro, M C (1998) Role of the vomeronasal input in maternal behavior. Psychoneuroendocrinology 23:905-26
Cohen, F S; Yang, Z; Huang, Z et al. (1998) Automatic matching of homologous histological sections. IEEE Trans Biomed Eng 45:642-9
Ali, W S; Cohen, F S (1998) Registering coronal histological 2-D sections of a rat brain with coronal sections of a 3-D brain atlas using geometric curve invariants and B-spline representation. IEEE Trans Med Imaging 17:957-66
Shumsky, J S; Wu, Y; Murphy, E H et al. (1998) Prenatal cocaine exposure does not affect selected GABAA receptor subunit mRNA expression in rabbit visual cortex. Ann N Y Acad Sci 846:371-4

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