The broad, long term objectives of this application are to establish a nuclear magnetic resonance resource that will advance important areas of technological research and development, provide opportunities for collaborative research, and offer service and training to the basic research and clinical communities. Health care will benefit from improvements in knowledge of the structure and function of the body and brain and in medical technology.
The specific aims are (1) to establish a 4 tesla whole-body imaging and spectroscopy resource and to evaluate its capabilities, (2) to develop the technology and applications of NMR microscopy, (3) to further advance the technology of relaxation dispersion measurements and to make improved instrumentation available to all those who need it, (4) to provide proven quantitative methodology for basic and clinical in vitro and in vivo NMR spectroscopy, (5) to provide a firm theoretical basis for microscopic imaging and contrast agent development, and (6) to develop new and improved methods of imaging, image processing, and image analysis and visualization for multidimensional NMR and other modalities.
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|Li, Li; Boniecki, Michal T; Jaffe, Jacob D et al. (2011) Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites. Proc Natl Acad Sci U S A 108:9378-83|
|Sallam, Khalid Ibrahim (2007) Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control 18:566-575|
|Sallam, Khalid Ibrahim (2007) Chemical, sensory and shelf life evaluation of sliced salmon treated with salts of organic acids. Food Chem 101:592-600|
|Sallam, Kh I; Samejima, K (2004) Microbiological and chemical quality of ground beef treated with sodium lactate and sodium chloride during refrigerated storage. Lebenson Wiss Technol 37:865-871|
|Moser, Kevin W; Georgiadis, John G (2004) Extraction and validation of correlation lengths from interstitial velocity fields using diffusion-weighted MRI. Magn Reson Imaging 22:257-68|
|Sallam, Kh I; Ishioroshi, M; Samejima, K (2004) Antioxidant and antimicrobial effects of garlic in chicken sausage. Lebenson Wiss Technol 37:849-855|
|Sallam, Khalid Ibrahim; Samejima, Kunihiko (2004) Effects of Trisodium Phosphate and Sodium Chloride Dipping on the Microbial Quality and Shelf Life of Refrigerated Tray-packaged Chicken Breasts. Food Sci Biotechnol 13:425-429|
|Wang, Steven J; Brechbiel, Martin; Wiener, Erik C (2003) Characteristics of a new MRI contrast agent prepared from polypropyleneimine dendrimers, generation 2. Invest Radiol 38:662-8|
|Swain, R A; Harris, A B; Wiener, E C et al. (2003) Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 117:1037-46|
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