This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
We aim to study the mesoscopic dynamics associated with the clotting of blood in capillary vessels. Fibrin aggregation plays a great role in modifying the physical properties of blood. Our model of blood consists of the plasmas represented by the fluid particles and the red blood cells, modelled with the elastic mesh of 'solid' particles. the particle-on string model is used for constructingthe wallsof capillary vessels. The fluid particles interact with each other with a short-range , repulsive dissipative force, which depends on the fibrin concentration. The polymerization of fibrin monomers inot hydrated fibrins by the change of interactions between fluid paricles from repulsive to attractive forces. the fluid particle model has been tested on 16 processors of SGI Origin 3800, IBM Regatta, and SGIAltix 3000. The tests were carried out ona relatively small system of two million fluid abd solid particles. Modelling of blood clotting in bifurcating vessels with realistic scales will require simulations involving over 100 million particles. Such calculations will open our eyes to blood clotting process and will alsomany more processors and memory.
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