This proposal is submitted in response to RFA-ES-10-010, entitled """"""""Superfund Hazardous Substance Research and Training Program (P42)."""""""" The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS);2) Consequences of As and Mn Exposure on Children's Health;and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic;5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites;and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management;9) Trace Metals;10) Biogeochemistry;and 11) Hydrogeology. A Research Translation Core (RTC) entitled, """"""""Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater"""""""" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled """"""""Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine."""""""" The CEC has developed naturally from our past biomedical and geochemical As research in Maine.

Public Health Relevance

The contamination of groundwater and soils with As and Mn are associated with major public health, remedial, and environmental policy problems. Both As and Mn are found at numerous Superfund sites. This competitive renewal proposal seeks to obtain fundamental new knowledge concerning the health effects, geochemistry, and remediation of As and Mn, with a particular focus on groundwater. Knowledge obtained from this research will have direct implications for remediation at contaminated sites and for the improvement of public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES010349-11S1
Application #
8538198
Study Section
Special Emphasis Panel (ZES1-JAB-J (SF))
Program Officer
Carlin, Danielle J
Project Start
2000-06-01
Project End
2017-03-31
Budget Start
2012-09-21
Budget End
2013-03-31
Support Year
11
Fiscal Year
2012
Total Cost
$170,929
Indirect Cost
$39,724
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Niedzwiecki, Megan M; Liu, Xinhua; Zhu, Huiping et al. (2018) Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study. Environ Int 113:133-142
Shoenfelt, Elizabeth M; Winckler, Gisela; Lamy, Frank et al. (2018) Highly bioavailable dust-borne iron delivered to the Southern Ocean during glacial periods. Proc Natl Acad Sci U S A 115:11180-11185
Haque, Ezazul; Mailloux, Brian J; de Wolff, Daisy et al. (2018) Quantitative drinking water arsenic concentrations in field environments using mobile phone photometry of field kits. Sci Total Environ 618:579-585

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