New nanomaterials offer promise as enabling components in next-generation environmental technologies, but may also pose health risks of their own through unintended exposure. Project 6 uses modern methods of nanosynthesis to create, characterize, and formulate new materials for study of both their implications and applications to environmental health and safety. In the initial funding period, a panel of nanomaterial and nanostructured material sorbents was created and evaluated for capture of vapor phase mercury. Ozone-treated carbon and nanoscale Ag, Cu, Ni, S, and Se were shown to have much higher adsorption capacities than conventional versions of the same materials, and one nanosorbent formulation (unstabilized, amorphous nano-selenium) had fifty-fold higher activity than any sorbent commercially available today. The renewal will investigate the detailed mechanisms of Hg/nanomaterial reactions with emphasis on creating new technologies for aqueous-phase mercury removal in collaboration with Project 5 and new technologies for managing the mercury released from fluorescent lamps that break during handling, use, or end-of-life disposal. In the area of nanotechnology implications, techniques were developed to quantify metal bioavailability and identify the role of hydrophobic surface area in the toxicity of carbon nanotubes. Research was also carried out on safer nanomaterial formulations including new purification protocols that detoxify nanotubes through targeted removal of bioavailable metal, functionalization of nanotubes to suppress folate adsorption that inhibits cell proliferation, and the use of TPGS as a new anti-oxidant surfactant for """"""""green"""""""" aqueous nanotube processing, all in close collaboration with Project 2. In the next funding period, we hypothesize that the biological response to nanoscale nickel, nickel oxide, chromate, and Ni/Y-containing carbon nanotubes will depend on size, surface state, and specific formulation. Alternative formulations will be prepared through annealing, oxidation, purification, and covalent and noncovalent surface modification, and the behavior of the materials will be studied in complex biological and environmental fluid phase simulants. A joint goal of Projects 2, 4, and 6 is to understand the materials and molecular bases for nanotoxicity through iterative nanomaterial formulation and biological testing. It is anticipated that this iterative and collaborative process will lead to nanomaterial structure/activity relations and general rules for safe nanomaterial design.
The over-arching goal of this Superfund Basic Research Program is to address health concerns, and to design novel remediation techniques, related to mixed exposures arising from contaminated lands and buildings, using Rhode Island as a model for appropriate research, educational, and training interventions. Project 6 draws from institutional core competencies in nanotechnology to address environmental health issues that are both current (mercury exposure) and anticipated (nanomaterial exposure and hazard).
|Toral-Sánchez, E; Rangel-Mendez, J R; Hurt, Robert H et al. (2018) Novel application of magnetic nano-carbon composite as redox mediator in the reductive biodegradation of iopromide in anaerobic continuous systems. Appl Microbiol Biotechnol 102:8951-8961|
|Thompson, Marcella Remer; Schwartz Barcott, Donna (2018) The Role of the Nurse Scientist as a Knowledge Broker. J Nurs Scholarsh :|
|Spade, Daniel J; Dere, Edward; Hall, Susan J et al. (2018) All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. I: Altered seminiferous cord maturation and testicular cell fate. Toxicol Sci :|
|Spade, Daniel J; Bai, Cathy Yue; Lambright, Christy et al. (2018) Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. Toxicol Lett 290:55-61|
|Sears, Clara G; Braun, Joseph M; Ryan, Patrick H et al. (2018) The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int 121:574-581|
|Guelfo, Jennifer L; Adamson, David T (2018) Evaluation of a national data set for insights into sources, composition, and concentrations of per- and polyfluoroalkyl substances (PFASs) in U.S. drinking water. Environ Pollut 236:505-513|
|Guelfo, Jennifer L; Marlow, Thomas; Klein, David M et al. (2018) Evaluation and Management Strategies for Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water Aquifers: Perspectives from Impacted U.S. Northeast Communities. Environ Health Perspect 126:065001|
|Chen, Po-Yen; Zhang, Mengke; Liu, Muchun et al. (2018) Ultrastretchable Graphene-Based Molecular Barriers for Chemical Protection, Detection, and Actuation. ACS Nano 12:234-244|
|Wilson, Shelby; Dere, Edward; Klein, David et al. (2018) Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome. Biol Reprod 99:266-268|
|Kane, Agnes B; Hurt, Robert H; Gao, Huajian (2018) The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 361:68-80|
Showing the most recent 10 out of 210 publications