Ensuring the successful development of the next generation of innovative research ideas and young scientists is critical to the continued advancement of high-impact translational science in neuroAIDS and addictions. Building on TMARC's success in supporting pilot studies and junior investigators during the past funding period, we propose to establish a formal Pilot and Developmental (PAD) Core for the renewal. The PAD Core will enable TMARC to expand the scope, rigor, and effectiveness of its already strong investment in serving as a resource-efficient incubator for innovative pilot studies and shaping individually-tailored developmental activities for trainees and junior investigators that will foster their professional growth in neuroAIDS and addictions research. Leadership of the PAD Core is multidisciplinary and brings considerable prior experience in training and the administration of developmental activities. The developmental program will assist trainees and junior investigators in matching with appropriate mentors and accessing TMARC scientific resources. The pilot grant program will involve annual calls for applications, which will Undergo formal scientific review by a nationally-recognized panel of external experts, the resource economy of which will be facilitated by linking the TMARC PAD Core to that of the HIV Neurobehavioral Research Center. After external review, the TMARC scientific leadership will evaluate highly rated proposals for their relevance to the Center's over-arching translational scientific aims and available resources before final funding recommendations are offered to NIDA program staff. In the current application, the PAD Core anticipates proposing 5 novel pilot studies for Year 1 that address issues germane to TMARC's METH/HIV aims, including real-world functioning (ludicello), cerebrovascular imaging (Croteau), social cognition (Sanders), cellular aging (Schrier), and vasculopathy (Soontornniyomkij). Each pilot: a) underwent a rigorous review process;b) is led by a junior investigator;c) has the potential to support external grant applications;and d) leverages the transdisciplinary resources of the Cores and Projects that support it. Abstracts of the Pilot Studies are found in the following pages.

Public Health Relevance

The TMARC PAD Core supports small-scale, innovative studies led by junior scientists that relate to HIV and METH effects on the brain. The PAD Core also for fosters the professional development of promising young scientists. By providing mentorship and multidisciplinary training opportunities, the PAD Core will help foster the next generation of investigators focusing on translational science in HIV and METH

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1)
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University of California San Diego
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Walker, Keenan A; Brown, Gregory G (2018) HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis. J Clin Exp Neuropsychol 40:357-376
Stecher, Melanie; Hoenigl, Martin; Eis-Hübinger, Anna Maria et al. (2018) Hotspots of Transmission Driving the Local Hiv Epidemic in the Cologne-Bonn Region, Germany. Clin Infect Dis :
Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108
Thaney, Victoria E; Kaul, Marcus (2018) Type I Interferons in NeuroHIV. Viral Immunol :
Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2018) Association of antiretroviral therapy with brain aging changes among HIV-infected adults. AIDS 32:2005-2015
Thaney, Victoria E; Sanchez, Ana B; Fields, Jerel A et al. (2018) Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol 24:156-167
Kesby, James P; Chang, Ariel; Markou, Athina et al. (2018) Modeling human methamphetamine use patterns in mice: chronic and binge methamphetamine exposure, reward function and neurochemistry. Addict Biol 23:206-218
Hoenigl, Martin; Jain, Sonia; Moore, David et al. (2018) Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men1. Emerg Infect Dis 24:
Moore, David J; Pasipanodya, Elizabeth C; Umlauf, Anya et al. (2018) Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial. Drug Alcohol Depend 189:154-160
MacDuffie, Katherine E; Brown, Gregory G; McKenna, Benjamin S et al. (2018) Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. Neuroimage Clin 20:1044-1052

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