Abstract

?s narrative) The purpose of this core is to provide centralized care, breeding, genotyping and quality control of inbred rat strains, and transgenic and knockout mice used by investigators in the Center. The core will provide a mechanism for the distribution of new experimental transgenic and knockout models to Center and non-Center investigators both at the University of Iowa and outside the institution. The main responsibilities of the core will be: 1) generation of new transgenic models; 2) maintenance of genetic stocks of rats and mice; 3) genotyping transgenic and knockout mice; 4) generation of compound mutants and transgenics 5) provision of experimental and control mice to investigators; and 6) quality control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL055006-10
Application #
7008219
Study Section
Project Start
Project End
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
10
Fiscal Year
2005
Total Cost
$139,750
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Mark, Allyn L (2013) Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol 305:R566-81
Hingtgen, Shawn D; Li, Zhenbo; Kutschke, William et al. (2010) Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NF-?B activation and cardiac hypertrophy. Physiol Genomics 41:127-36
Lindley, Timothy E; Infanger, David W; Rishniw, Mark et al. (2009) Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction. Am J Physiol Regul Integr Comp Physiol 296:R1-8
Bianco, Robert A; Agassandian, Khristofor; Cassell, Martin D et al. (2009) Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain Res 1291:60-72
Halabi, Carmen M; Beyer, Andreas M; de Lange, Willem J et al. (2008) Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab 7:215-26
Zhou, Xiyou; Sigmund, Curt D (2008) Chorionic enhancer is dispensable for regulated expression of the human renin gene. Am J Physiol Regul Integr Comp Physiol 294:R279-87
de Lange, Willem J; Halabi, Carmen M; Beyer, Andreas M et al. (2008) Germ Line Activation of the Tie2 and SMMHC Promoters Causes Non-Cell Specific Deletion of Floxed Alleles. Physiol Genomics :
Wakisaka, Yoshinobu; Miller, Jordan D; Chu, Yi et al. (2008) Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. J Cereb Blood Flow Metab 28:1175-85
Grobe, Justin L; Xu, Di; Sigmund, Curt D (2008) An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda) 23:187-93
Shi, Peijun P; Cao, Xiao R; Sweezer, Eileen M et al. (2008) Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol 295:F462-70

Showing the most recent 10 out of 183 publications