The Clinical Research Center of the Philadelphia Geriatric Center/Medical College of Pennsylvania is devoted to research on the mental health and psychopathology of older people in residential care. The original 3 years of the CRC focused on depression, while the proposed continuation will continue some of this research and move to include other problematic conditions such as mixed depression and dementia and early dementia. The continuation builds on the initial integration of biomedical and psychosocial themes as well as basic, applied, and intervention- research approaches. 8 pilot projects will be included. 4 will have a biomedical focus but all will have a clear behavioral component: A continuation of a program of research on the risks and side affects of psychoactive medication; a study of amino acid metabolism in the psychopathology of this age group; a study of HPA and immune functions; and a study of light in relation to phase advancement, sleep, and depression. The latter study also has a focus on the ecology of lighting in the institutional environment and is one of 5 with a major psychosocial focus. The others will investigate staff as a component of long-term care; staff and residents' readiness to engage in a program to enhance personal control; a study of the temporal relationships between physical health and affective states; and an ethnographic study of the experience and meaning of depression. These projects are supported by a Core with formal assessments of the near-universe of resident and newly-admitted people, a data base that generates its own research in addition to the pilots. Core and activities will enhance the ability of the CRC to generate new research, give supervised research experience to new scientists, and disseminate research and methodological knowledge to other scientists and practitioners. A program of seed-money funding and progress reviews conducted to stimulate new pilot projects is proposed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH040380-05
Application #
3107135
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1985-08-01
Project End
1991-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Madlyn/Leonard Abramson Center/Jewish Life
Department
Type
DUNS #
City
North Wales
State
PA
Country
United States
Zip Code
19454
Wang, H Y; Bashore, T R; Tran, Z V et al. (2000) Age-related decreases in lymphocyte protein kinase C activity and translocation are reduced by aerobic fitness. J Gerontol A Biol Sci Med Sci 55:B545-51
Wang, H Y; Friedman, E (1996) Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry 40:568-75
Lawton, M P; Parmelee, P A; Katz, I R et al. (1996) Affective states in normal and depressed older people. J Gerontol B Psychol Sci Soc Sci 51:P309-16
Friedman, E; Wang, H Y (1996) Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J Neurochem 67:1145-52
Casten, R J; Parmelee, P A; Kleban, M H et al. (1995) The relationships among anxiety, depression, and pain in a geriatric institutionalized sample. Pain 61:271-6
Wang, H Y; Bashore, T R; Friedman, E (1995) Exercise reduces age-dependent decrease in platelet protein kinase C activity and translocation. J Gerontol A Biol Sci Med Sci 50A:M12-6
Luborsky, M R (1995) The process of self-report of impairment in clinical research. Soc Sci Med 40:1447-59
Wang, H Y; Pisano, M R; Friedman, E (1994) Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-8
Katz, I R; Streim, J; Parmelee, P (1994) Prevention of depression, recurrences, and complications in late life. Prev Med 23:743-50
Katz, I R; Parmelee, P A; Beaston-Wimmer, P et al. (1994) Association of antidepressants and other medications with mortality in the residential-care elderly. J Geriatr Psychiatry Neurol 7:221-6

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