Abstract

The Philadelphia Geriatric Center (PGC) - Medical College of Pennsylvania (MCP) Clinical Research Center proposes a program of multidisciplinary research on the psychiatric disorders of the elderly, focusing primarily on those patients who require residential care. The long-term goals of the CRC are: (1) to develop new knowledge on depression, dementia, and the other psychiatric disorders of the aged; (2) to perform research of clinical relevance; (3) to stimulate new research, and (4) to train new scientists in geriatric mental health. The CRC consists of a Core and four laboratories. The functions of the Core include administration of the Center, education, support of the investigations of the laboratories, and the conduct of its own research. The four laboratories are: (1) Laboratory of Health and Affect, directed by Powell Lawton; (2) Laboratory of Psychosocial Processes, directed by Patricia Parmelee; (3) Laboratory of Cognitive Neuroscience, directed by Diana Woodruff-Pak, and (4) Laboratory of Biological Psychiatry, directed by George Simpson and Ira Katz. The Core and each of the Laboratories are described in their own sections. The introduction and overview to the total project presents the goals of the Center, reviews its history and evolution, outlines its structure, and describes its relationship with the parent institutions and with clinical services at PGC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
2P50MH040380-07
Application #
3107132
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1985-08-01
Project End
1993-07-31
Budget Start
1991-09-30
Budget End
1992-07-31
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Madlyn/Leonard Abramson Center/Jewish Life
Department
Type
DUNS #
City
North Wales
State
PA
Country
United States
Zip Code
19454

  Publications

Wang, H Y; Bashore, T R; Tran, Z V et al. (2000) Age-related decreases in lymphocyte protein kinase C activity and translocation are reduced by aerobic fitness. J Gerontol A Biol Sci Med Sci 55:B545-51
Wang, H Y; Friedman, E (1996) Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry 40:568-75
Lawton, M P; Parmelee, P A; Katz, I R et al. (1996) Affective states in normal and depressed older people. J Gerontol B Psychol Sci Soc Sci 51:P309-16
Friedman, E; Wang, H Y (1996) Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J Neurochem 67:1145-52
Casten, R J; Parmelee, P A; Kleban, M H et al. (1995) The relationships among anxiety, depression, and pain in a geriatric institutionalized sample. Pain 61:271-6
Wang, H Y; Bashore, T R; Friedman, E (1995) Exercise reduces age-dependent decrease in platelet protein kinase C activity and translocation. J Gerontol A Biol Sci Med Sci 50A:M12-6
Luborsky, M R (1995) The process of self-report of impairment in clinical research. Soc Sci Med 40:1447-59
Wang, H Y; Pisano, M R; Friedman, E (1994) Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-8
Katz, I R; Streim, J; Parmelee, P (1994) Prevention of depression, recurrences, and complications in late life. Prev Med 23:743-50
Katz, I R; Parmelee, P A; Beaston-Wimmer, P et al. (1994) Association of antidepressants and other medications with mortality in the residential-care elderly. J Geriatr Psychiatry Neurol 7:221-6

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