The goal of this Motor Neuron Disease (MND) Program Project Grant is to delineate principles underlying the selective vulnerability of the motor neuron. We plan to elucidate motor neuron-specific properties as well as factors that specifically act on motor neurons. The grant topics are: Core A - A clinical and pathological core that acts as a source of clinical information and specimens for members of the Program Project; the core also includes study of the characteristics of MND, the post- poliomyelitis syndrome, and medical ethical issues related to life- sustaining therapy in MND. Project #1 (Siddique) - An RFLP linkage study of familial MND. Project #3 (Gurney) - Neuroleukin (MND growth factor) and its relationship to MND survival and sprouting. Project #4 (Stefansson) Motor neuron-specific proteins and their relationship to motor neuron injury and neurite outgrowth. Project #5 (Roos) - Theiler's virus genes and gene products which determine neurotropism and neurovirulence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS021442-04
Application #
3107791
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1984-12-01
Project End
1992-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Thomas, Ajit G; Bodner, Amos; Ghadge, Ghanashyam et al. (2009) GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol 15:449-57
Haley, Benjamin; Paunesku, Tatjana; Proti?, Miroslava et al. (2009) Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair. Int J Radiat Biol 85:643-55
Paunesku, T; Chang-Liu, C M; Shearin-Jones, P et al. (2000) Identification of genes regulated by UV/salicylic acid. Int J Radiat Biol 76:189-98
Glaum, S R; Brooks, P A (1996) Tetanus-induced sustained potentiation of monosynaptic inhibitory transmission in the rat medulla: evidence for a presynaptic locus. J Neurophysiol 76:30-8
Brooks, P A; Glaum, S R (1995) GABAB receptors modulate a tetanus-induced sustained potentiation of monosynaptic inhibitory transmission in the rat nucleus tractus solitarii in vitro. J Auton Nerv Syst 54:16-26
Glaum, S R; Miller, R J (1995) Presynaptic metabotropic glutamate receptors modulate omega-conotoxin-GVIA-insensitive calcium channels in the rat medulla. Neuropharmacology 34:953-64
Siddique, T (1991) Molecular genetics of familial amyotrophic lateral sclerosis. Adv Neurol 56:227-31