The Translational Methods/Facilities (TMF) Core will provide state of the art genetic analysis as well asmouse model development, characterization and assessment for all components of the Consortium forNeuropsychiatric Phenomics. Three distinct but interactive units operationally define the specific aims of theTMF-Core: The Genetic Studies Unit will be responsible for generating and analyzing all genetic data in themultiple association studies to be conducted by the Consortium. The BAG Transgenic Unit will create novel murine models using BAG transgenes or by crossingestablished mutant lines to a) test the cellular etiology of genotype/phenotype associations by geneticrescue strategies, b) drive cell-specific expression of fluorescent proteins to identify CNS circuitry thatmay be perturbed via mutant genes and c) model the contribution of candidate genes identifiedand/or anticipated from ongoing genetic association analysis to significantly modify memoryprocesses or response inhibition. The Rodent Phenotyping Unit in close collaboration with the Human Translational Applications Corewill design, validate and conduct behavioral assays to phenotype mouse models used by theConsortium.The three units leverage considerable physical and intellectual resources at UCLA. Such leveraging willenable the TMF-Core to cost-effectively and efficiently provide informational genetic/phenotype databases,shared animal models and validated behavioral assessments throughout the Consortium and subsequentlyto the research community outside of UCLA.
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